Method for non-invasive monitoring of blood and tissue glucose

• US 20050027183A1
• Filed: 06/30/2004
• Published: 02/03/2005
• Est. Priority Date: 07/01/2003
• Status: Abandoned Application

• Current Assignee: Midwest Research Institute
• Original Assignee: Midwest Research Institute
• Inventors: Sastre, Antonio
• Application Number:
  US10/881,514
• Publication Number:
  US 20050027183A1
• Time in Patent Office: Days
• US Class Current: 600/365
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/333 Recording apparatus specially adapted therefor
• CPC Class Codes: A61B 5/726 using Wavelet transforms

Abstract

The present invention provides a non-invasive real-time physiologic measure of blood and tissue glucose wherein measurements of heart rate variability are utilized to track changes in blood and tissue glucose.

Claims

1. A non-invasive physiologic method for determining blood glucose levels comprising:

computing non-conventional measures of the heart rate variability of an individual over time; and

correlating said heart rate variability with the individual'"'"'s blood glucose level.

2. A non-invasive physiologic method for determining blood glucose levels comprising:

(a) measuring the cardiac interbeat interval of an individual;

(b) performing a wavelet transform of the interbeat interval data measured in step (a) above;

(c) extracting the Holder exponents from the wavelet transformed interbeat interval data measured in step (a) above; and

(d) correlating the raw time series of said Holder exponent with the individual'"'"'s blood glucose level.