Methods and compositions comprising monitoring devices

• US 20050031536A1
• Filed: 07/07/2004
• Published: 02/10/2005
• Est. Priority Date: 12/21/1998
• Status: Abandoned Application

• Current Assignee: Candace Mccombs, Joseph R. Lakowicz, Omoefe Abugo, Zygmunt Gryczynski
• Original Assignee: Candace Mccombs, Joseph R. Lakowicz, Omoefe Abugo, Zygmunt Gryczynski
• Inventors: McCombs, Candace, Abugo, Omoefe, Gryczynski, Zygmunt, Lakowicz, Joseph R.
• Application Number:
  US10/886,388
• Publication Number:
  US 20050031536A1
• Time in Patent Office: Days
• US Class Current: 424/9.100
• CPC Class Codes: A61B 5/0071 by measuring fluorescence emission
• CPC Class Codes: A61B 5/4833 Assessment of subject's compliance to treatment
• CPC Class Codes: A61B 5/681 Wristwatch-type devices
• CPC Class Codes: A61K 49/0034 Indocyanine green, i.e. ICG, cardiogreen
• CPC Class Codes: A61K 49/0041 Xanthene dyes, used in vivo, e.g. administered to a mice, e.g. rhodamines, rose Bengal in vivo G01N
• CPC Class Codes: A61K 49/0063 characterised by a special physical or galenical form, e.g. emulsions, microspheres
• CPC Class Codes: A61K 49/0082 micelle, e.g. phospholipidic micelle and polymeric micelle
• CPC Class Codes: G16H 20/10 relating to drugs or medications, e.g. for ensuring correct administration to patients
• CPC Class Codes: G16H 40/63 for local operation
• CPC Class Codes: Y02A 90/10 Information and communication technologies [ICT] supporting adaptation to climate change, e.g. for weather forecasting or climate simulation

Abstract

Methods and compositions for the detection and monitoring of drug therapy are provided. In particular, efficient and sensitive methods for the detection of drug ingestion are provided for determining whether individuals are complying with prescribed therapeutic regimens, and for providing a mechanism for identifying drug-resistant strains of infectious agents. The claimed methods and compositions involve the application of transdermal devices containing detection mechanisms for receiving and recording signals generated by the ingestion of a labeled drug. Such devices are attached to the skin for the duration of drug therapy and compliance is determined either by direct reading, or by remote monitoring whereby signals are transmitted from the device and received at an external site such as a healthcare facility.

Claims

1. A method for monitoring therapeutic compliance comprising a transdermal detection device capable of receiving a signal from labeled medication.