Compositions and method for steroid homeostasis

• US 20050032743A1
• Filed: 08/26/2003
• Published: 02/10/2005
• Est. Priority Date: 08/27/2002
• Status: Abandoned Application

• Current Assignee: VDF FutureCeuticals Incorporated (VDF FutureCueticals Incorporated)
• Original Assignee: VDF FutureCeuticals Incorporated (VDF FutureCueticals Incorporated)
• Inventors: Miljkovic, Dusan
• Application Number:
  US10/648,975
• Publication Number:
  US 20050032743A1
• Time in Patent Office: Days
• US Class Current: 514/54
• CPC Class Codes: A23L 33/155 Vitamins A or D
• CPC Class Codes: A23L 33/165 Complexes or chelates
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2250/1572 Boron
• CPC Class Codes: A23V 2250/1578 Calcium
• CPC Class Codes: A23V 2250/161 Magnesium
• CPC Class Codes: A23V 2250/71 Vitamin D
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/59 Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
• CPC Class Codes: A61K 31/69 Boron compounds
• CPC Class Codes: A61K 31/715 Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

Abstract

Methods and compositions are directed to a dietary supplement comprising boron that is an a complex with a carbohydrate, wherein administration of the complex increases steroid levels, and particularly 25-hydroxy vitamin D3. Thus, contemplated compositions are useful for treatment of impaired steroid homeostasis, and especially beneficial for prevention and/or treatment of bone density loss. Particularly preferred compositions further include calcium, magnesium, and/or vitamin D in a nutritionally acceptable form.

Claims

1. A dietary supplement comprising:

an isolated carbohydrate-boron complex having a boron portion and at least one carbohydrate ligand complexed to the boron portion with a boron-ligand association constant of at least 50;

wherein the carbohydrate-boron complex is present in the dietary supplement in an amount sufficient to increase a plasma steroid concentration of a human ingesting the dietary supplement; and

at least one of a nutritionally acceptable form of calcium, magnesium, and vitamin D.

2. The dietary supplement of claim 1 wherein the carbohydrate ligand is selected from the group consisting of fructose, mannose, mannitol, sorbose, and sorbitol.

3. The dietary supplement of claim 2 wherein the carbohydrate-boron complex is a calcium salt of fructoborate.

4. The dietary supplement of claim 3 comprising the nutritionally acceptable form of calcium.

5. The dietary supplement of claim 3 comprising the nutritionally acceptable form of magnesium.

6. The dietary supplement of claim 3 comprising the nutritionally acceptable form of Vitamin D.

7. The dietary supplement of claim 3 wherein the steroid is 25-hydroxy-vitamin D3, and wherein the increase is at least 10%.

8. The dietary supplement of claim 3 wherein the steroid is testosterone, and wherein the increase is at least 10%.

9. The dietary supplement of claim 3 wherein the increase of the steroid concentration stimulates an increase in bone density.

10. The dietary supplement of claim 1 wherein the carbohydrate-boron complex and the at least one of a nutritionally acceptable form of calcium, magnesium, and vitamin D are combined in a tablet or capsule.

11. The dietary supplement of claim 1 wherein the carbohydrate-boron complex is present at an amount sufficient to increase bone density.

12. A method of increasing a steroid concentration in a human, comprising:

providing an isolated carbohydrate-boron complex having a boron portion and at least one carbohydrate ligand complexed to the boron portion with a boron-ligand association constant of at least 50; and

providing an instruction to administer the carbohydrate-boron complex under a protocol that increases the steroid concentration in the human.

13. The method of claim 12 wherein the carbohydrate ligand is selected from the group consisting of fructose, mannose, mannitol, sorbose, and sorbitol.

14. The method of claim 13 wherein the carbohydrate-boron complex is a calcium salt of fructoborate.

15. The method of claim 12 wherein the protocol comprises daily oral administration of at least 1 mg of the carbohydrate-boron complex over at least 30 days.

16. The method of claim 12 further comprising a step of co-administering at least one of a nutritionally acceptable form of calcium, magnesium, and vitamin D.

17. The method of claim 12 wherein the steroid is at least one of a testosterone, an estrogen, and a 25-hydroxy vitamin D3, and wherein the increase in the steroid concentration stimulates an increase in bone density in the human.

18. A method of marketing a dietary supplement, comprising:

providing at least one of a dietary supplement selected from the group of a nutritionally acceptable form of boron, calcium, magnesium, and vitamin D;

providing printed information that a combination of the nutritionally acceptable form of boron with at least one of the nutritionally acceptable form of calcium, magnesium, and vitamin D promotes bone health; and

wherein the nutritionally acceptable form of boron comprises an isolated carbohydrate-boron complex having a boron portion and at least one carbohydrate ligand complexed to the boron portion with a boron-ligand association constant of at least 250.

19. The method of claim 18 wherein the printed information further includes information that the nutritionally acceptable form of boron increases a steroid concentration in the human.

20. The method of claim 19 wherein the steroid is at least one of a testosterone, an estrogen, and a 25-hydroxy vitamin D3.