Analyte measuring device
First Claim
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1. A device for subcutaneous monitoring of glucose levels, comprising a housing and a sensor, the sensor comprising an angiogenic layer for promoting adequate microcirculatory delivery of glucose and oxygen to the sensor, wherein the angiogenic layer further comprises a bioactive agent.
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Abstract
An implantable analyte-measuring device including a membrane adapted to promote vascularization and/or interfere with barrier cell layer formation. The membrane includes any combination of materials, architecture, and bioactive agents that facilitate analyte transport to provide long-term in vivo performance of the implantable analyte-measuring device.
948 Citations
80 Claims
- 1. A device for subcutaneous monitoring of glucose levels, comprising a housing and a sensor, the sensor comprising an angiogenic layer for promoting adequate microcirculatory delivery of glucose and oxygen to the sensor, wherein the angiogenic layer further comprises a bioactive agent.
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32. A device for subcutaneous monitoring of a glucose level, comprising a housing and a sensor, the sensor comprising a first domain, a second domain, and a bioactive agent;
- wherein the first domain supports tissue ingrowth and is positioned more distal to the housing than the second domain;
wherein the second domain is substantially impermeable to macrophages and is situated between the first domain and the housing, and wherein the bioactive agent is incorporated within at least one of the first domain, the second domain, and the sensor. - View Dependent Claims (33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60)
- wherein the first domain supports tissue ingrowth and is positioned more distal to the housing than the second domain;
- 61. A device for subcutaneous monitoring of glucose levels, comprising a housing, a sensor, and an an angiogenic layer for promoting adequate microcirculatory delivery of glucose and oxygen to the sensor, wherein the angiogenic layer is configured to promote vascularization in or around the angiogenic layer so as to maintain sufficient blood flow to the sensor for glucose measurement thereby.
Specification