Method of treating depression, mood disorders and anxiety disorders using neuromodulation

• US 20050033379A1
• Filed: 06/18/2004
• Published: 02/10/2005
• Est. Priority Date: 06/19/2003
• Status: Abandoned Application

• Current Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Advanced Neuromodulation Systems Incorporated (Abbott Laboratories Incorporated)
• Inventors: Lozano, Andres M., Mayberg, Helen S.
• Application Number:
  US10/872,271
• Publication Number:
  US 20050033379A1
• Time in Patent Office: Days
• US Class Current: 607/45
• CPC Class Codes: A61B 5/4848 Monitoring or testing the effects of treatment, e.g. of medication
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61N 1/0534 Electrodes for deep brain stimulation
• CPC Class Codes: A61N 1/36096 Mood disorders, e.g. depression, anxiety or panic disorder
• CPC Class Codes: A61N 1/36185 Selection of the electrode configuration
• CPC Class Codes: A61P 25/00 Drugs for disorders of the nervous system
• CPC Class Codes: A61P 25/24 Antidepressants

Abstract

The present invention involves a method and a system for using electrical stimulation and/or chemical stimulation to treat depression. More particularly, the method comprises surgically implanting an electrical stimulation lead and/or catheter that is in communication with a predetermined site which is coupled to a signal generator and/or infusion pump that release either an electrical signal and/or a pharmaceutical resulting in stimulation of the predetermined site thereby treating the mood and/or anxiety.

Claims

1. A system for treating a mood and/or anxiety disorder comprising:

a probe having a stimulation portion in communication with a subcallosal area; and

a device to stimulate the probe thereby stimulating the subcallosal area and treating the mood and/or anxiety disorder.

2. The system of claim 1, wherein the probe is coupled to the device.

3. The system of claim 1, wherein the probe is incorporated within the device.

4. The system of claim 1, wherein the device is an electrical signal source or a pharmaceutical delivery pump.

5. The system of claim 1, wherein the device is a combination of an electrical signal source and a pharmaceutical delivery pump.

6. The system of claim 1, wherein the probe is an electrical stimulation lead.

7. The system of claim 1, wherein the probe is a pharmaceutical catheter.

8. The system of claim 6, wherein the lead comprises a plurality of electrodes.

9. The system of claim 7, wherein the catheter comprises at least one electrode.

10. The system of claim 1, wherein the stimulation is electrical.

11. The system of claim 1, wherein the stimulation is chemical.

12. The system of claim 1, wherein the stimulation is magnetic.

13. A microstimulator for treating subjects with mood and/or anxiety disorders comprising:

an electrical stimulation lead having a stimulation portion in communication with a subcallosal area; and

an electrical signal generating portion to stimulate the probe thereby stimulating the subcallosal area and treating the mood and/or anxiety disorder, wherein the lead and the generating portion are combined in one unit.

14. The system of claim 13, wherein the generating portion further comprising a pharmaceutical delivery pump.

15. The system of claim 13, wherein the lead comprises a plurality of electrodes.

16. The system of claim 14, wherein the lead further comprises a catheter.

17. A system for treating subjects with mood and/or anxiety disorders comprising:

an electrical stimulation lead that is implanted into the subject'"'"'s brain, the lead comprises at least one electrode that is in communication with a subcallosal area and delivers an electrical signal to the subcallosal area in response to the received signal; and

a signal generator that generates the electrical signal for transmission to the at least one electrode of the lead resulting in delivery of the electrical signals to subcallosal area thereby treating the mood and/or anxiety disorder.

18. The system of claim 17, wherein the lead comprises a plurality of electrodes.

19. The system of claim 17, wherein the signal generator is implanted in the subject'"'"'s body.

20. The system of claim 17 further comprising:

a catheter that is implanted into a subject'"'"'s brain, the catheter having a proximal end coupled to a pump and a discharge portion for infusing a dosage of a pharmaceutical is in communication with the subcallosal area and a pump to discharge the pharmaceutical through the discharge portion of the catheter into the predetermined site thereby chemically stimulating the subcallosal area and treating the mood and/or anxiety disorder.

21. A system for treating subjects with mood and/or anxiety disorders comprising:

an electrical stimulation lead that is implanted into the subject'"'"'s brain, the lead comprises at least one electrode that is in communication with Brodmann area 25 and delivers an electrical signal to Brodmann area 25 in response to the received signal; and

a signal generator that generates the electrical signal for transmission to the at least one electrode of the lead resulting in delivery of the electrical signals to Brodmann area 25 thereby treating the mood and/or anxiety disorder.

22. A system for treating subjects with mood and/or anxiety disorder comprising:

a catheter that is implanted into a subject'"'"'s brain, the catheter having a proximal end coupled to a pump and a discharge portion for infusing a dosage of a pharmaceutical is in communication with a subcallosal area; and

a pump to discharge the pharmaceutical through the discharge portion of the catheter into the predetermined site thereby chemically stimulating the subcallosal area and treating the mood and/or anxiety disorder.

23. The system of claim 22, wherein the catheter further comprises an electrical stimulation lead having at least one electrode.

24. The system of claim 23 further comprising a signal generator that generates signals for transmission to the electrode of the lead resulting in delivery of electrical signals to the subcallosal thereby treating the mood and/or anxiety disorder.

25. A system for treating subjects with mood disorder and/or anxiety disorder comprising:

an electrical stimulation lead that is implanted into the subject'"'"'s brain, the lead comprises at least one electrode that is in communication with a subcallosal area and delivers electrical signals to the predetermined site in response to received signals;

a signal generator that generates signals for transmission to the electrode of the lead resulting in delivery of electrical signals to the subcallosal area;

a catheter that is implanted into the subject'"'"'s brain, the catheter having a proximal end coupled to a pump and a discharge portion for infusing a dosage of a pharmaceutical is in communication with the subcallosal area; and

a pump to discharge the pharmaceutical through the discharge portion of the catheter into the subcallosal area;

wherein stimulation of subcallosal area treats the mood and/or anxiety disorder.

26. The system of claim 25, wherein the lead comprises a plurality of electrodes.

27. The system of claim 25, wherein the signal generator is implanted in the subject'"'"'s body.

28. The system of claim 25, wherein the pump is implanted in the subject'"'"'s body.