Hybrid stent

• US 20050033399A1
• Filed: 06/03/2004
• Published: 02/10/2005
• Est. Priority Date: 12/03/1998
• Status: Abandoned Application

• Current Assignee: Medinol Limited (Medinol USA Incorporated)
• Original Assignee: Medinol Limited (Medinol USA Incorporated)
• Inventors: Richter, Jacob
• Application Number:
  US10/860,735
• Publication Number:
  US 20050033399A1
• Time in Patent Office: Days
• US Class Current: 623/1.110
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2/915 with bands having a meander structure, adjacent bands being connected to each other
• CPC Class Codes: A61F 2002/826 more than one stent being applied sequentially
• CPC Class Codes: A61F 2002/828 Means for connecting a plurality of stents allowing flexibility of the whole structure
• CPC Class Codes: A61F 2002/91541 Adjacent bands are arranged out of phase
• CPC Class Codes: A61F 2002/91558 connected peak to peak
• CPC Class Codes: A61F 2210/0004 bioabsorbable
• CPC Class Codes: A61F 2250/0031 made from both resorbable and non-resorbable prosthetic parts, e.g. adjacent parts
• CPC Class Codes: A61F 2250/0071 breakable or frangible

Abstract

A stent is provided with a series of short pieces or sections connected together by a bioresorbable polymer. The stent sections are designed to separate or articulate with time as the polymer biodegrades. The time of separation can be controlled by the characteristics of the bioresorbable polymer to allow the stent to be buried in neo-intima. By using a tube made of a bioresorbable polymer, the continuous covering of the tubing may inhibit embolization in the first few weeks after stent implantation within the walls of a vessel and timing for removal of the tube through formulation of the bioresorbable polymer can be controlled to occur when embolization is no longer a risk. When the detachment of the stent pieces or sections occurs, they are fixedly secured within the vessel and each are able to flex with the vessel independently of the other stent segments.

Claims

1. A stent for implantation in a vessel, comprising:

a plurality of short stent sections; and

a material interconnecting said sections in an initially unitary stent structure, said material adapted to permit said sections to separate from each other in a controlled manner in response to physiological conditions placed on said structure.

2. The stent in claim 1, wherein said material is bioresorbable.

3. The stent in claim 2, wherein said bioresorbable material is in the form of tubing.

4. The stent in claim 1, wherein said period of time for separation of said plurality of segments is controlled by material characteristics of said bioresorbable material.

5. The stent in claim 1, wherein the material includes free spaces through which neointimal growth may be faster.

6. The stent in claim 1, wherein said plurality of sections are circumferential rings.

7. The stent in claim 1, wherein said plurality of sections are short sections of said structure.

8. The stent in claim 1, wherein each of said plurality of sections is formed of a single sinusoidal pattern.

9. The stent in claim 8, wherein each of said single sinusoidal patterns is uniform.

10. The stent in claim 8, wherein at least some of said single sinusoidal patterns have a different configuration from others.

11. The stent of claim 1, wherein each of said plurality of sections have a plurality of sinusoidal patterns.

12. The stent of claim 11, wherein each of said plurality of sinusoidal patterns are uniformly designed.

13. The stent of claim 11, wherein said plurality of sinusoidal patterns have a different configuration from others.

14. The stent of claim 11, wherein each of said plurality of sinusoidal patterns are differently designed within a stent section.

15. The stent of claim 1, wherein at least one of said plurality of sections has a plurality of sinusoidal patterns, and at least one of said plurality of sections has a single sinusoidal pattern.

16. The stent of claim 1, wherein said material includes a fenestration to promote faster growth of neo-intima.

17. The stent of claim 16, wherein said fenestration has a geometric shape or a size that promotes growth of the neo-intima.

18. The stent of claim 1, wherein said material is a bioresorbable polymer.

19. The stent of claim 1, wherein said material is a biodegradable polymer.

26. The stent of claim 1, wherein each stent section further comprises a first loop containing section with loops occurring at a first frequency and a second loop containing section with loops also occurring at said first frequency and a third loop containing section having loops occurring at a second frequency that is higher than said first frequency, said third loop containing section disposed between said first and second loop containing sections, and consecutively joined for at least two repetitions to said first and second loop containing sections.

27. The stent of claim 26, wherein said first and said third loop containing sections or said second and said third loop containing sections form at least one cell, said cell having an interior, and said high frequency loops are in a ratio of 3:

2 to said low frequency loops.

28. The stent of claim 26, wherein said higher frequency loop containing section is smaller in width compared to said lower frequency loop containing section.

29. The stent of claim 26, wherein said higher frequency loop containing section is 180 degrees out of phase with adjacent high frequency loop containing sections.

20. A stent for implantation in a vessel, comprising:

a plurality of individual pieces coupled by a bioresorbable polymer tubing; and

said bioresorbable polymer tubing adapted to permit said plurality of pieces to separate from each other in a controlled manner in response to physiological conditions placed on said bioresorbable polymer tubing, said separation occurs a period of time after implantation of the stent in the vessel, said period of time being sufficient to permit neo-intima formation around the stent in an amount sufficient to secure said plurality of stent segments with respect to the vessel.

21. The stent of claim 20, wherein said bioresorbable polymer tubing inhibits embolization.

22. The stent of claim 20, wherein said bioresorbable polymer tubing is fenestrated.

23. The stent of claim 20, wherein said bioresorbable tubing further includes a customized length.

24. The stent of claim 20, wherein said stent is balloon expanded or self-expanded.

25. The stent of claim 20, wherein each piece further comprises a plurality of sinusoidal patterns, said sinusoidal patterns are generally arranged in the circumferential direction of the stent and are periodically interconnected thereto.

30. A stent for implantation in a vessel, comprising:

a plurality of short sections;

a bioresorbable polymer tubing for detachably connecting adjacent said plurality of stent segments; and

said bioresorbable polymer tubing being fenestrated and adapted to permit said adjacent stent segments to separate from each other in a controlled manner in response to physiological conditions placed on said bioresorbable polymer tubing, said separation occurs a period of time after implantation of the stent in the vessel, said period of time being sufficient to permit neo-intima formation around the stent in an amount sufficient to secure said plurality of stent segments with respect to the vessel.

31. The stent of claim 30, wherein the bioresorbable polymer tubing is made of a polymer selected from the group consisting of polyesters, polyanhydrides, polyorthoesters, polyphosphazenes, and any combination thereof.

32. The stent of claim 30, wherein the bioresorbable polymer tubing is made of a polymer selected from the group consisting of polyglycolide, polylactide, polycaprolactone, polydioxanone, poly(lactide-co-glycolide), polyhydroxybutyrate, polyhydroxyvalerate, trimethylene carbonate, and any combination thereof.