Aneurysm treatment device and method of use

• US 20050033409A1
• Filed: 07/16/2004
• Published: 02/10/2005
• Est. Priority Date: 07/20/2001
• Status: Active Grant

• Current Assignee: Microvention Incorporated (Terumo Corporation)
• Original Assignee: Microvention Incorporated (Terumo Corporation)
• Inventors: Burke, Thomas H., Cox, Brian J., Ferrera, David, Fitz, Matthew J.
• Granted Patent: US 8,715,312 B2
• Time in Patent Office: Days
• US Class Current: 623/1.150
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12118 for positioning in conjunction with a stent
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12177 comprising additional materials, e.g. thrombogenic, having filaments, having fibers or being coated
• CPC Class Codes: A61B 17/12186 liquid materials adapted to be injected
• CPC Class Codes: A61B 17/1219 expandable in contact with liquids
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61F 2/82 Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents stent-grafts for tubular structures of the body other than blood vessels A61F2/04; stent-grafts for blood vessels A61F2/07; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95; for closing wounds, or holding wounds closed A61B17/04 - A61B17/115; dilators A61M29/00
• CPC Class Codes: A61F 2002/065 Y-shaped blood vessels
• CPC Class Codes: A61F 2002/823 Stents, different from stent-grafts, adapted to cover an aneurysm
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

The present application discloses an apparatus for treating vascular aneurysms and includes an occlusive support device comprised of one or more support members. The occlusive device has a first end portion and a second end portion, an end cap member at the first end portion of the occlusive support device, and an anchoring member at the second end portion. The end cap member is comprised of at least one of one or more of the support members. The end cap member has openings and the end cap member comprises a reactive material that is configured to hydrate upon delivery of the device and to reduce the size of said openings. The end cap member has an end cap diameter and the end cap is generally perpendicular to the longitudinal axis of the support device. The end cap has an extension along the longitudinal axis of said device that is less than two times the end cap diameter. The device is configured so that the occlusive members can be positioned in the blood vessel proximate the neck of a vascular aneurysm, the reactive material hydrates and increases the resistance to blood flow into the aneurysm, and the anchoring member anchors the device in the blood vessel without occluding flow through the blood vessel.

Claims

1. An apparatus for treating vascular aneurysms, comprising:

an occlusive support device comprising one or more support members forming a first end portion and a second end portion and defining a lumen therethrough; and

an end cap member at said first end portion of said occlusive support device;

wherein said end cap member has openings and said end cap member comprises a reactive material that is configured to hydrate upon delivery of the device and to reduce the size of said openings; and

an anchoring member at said second end portion.

2. The apparatus of claim 1 wherein said end cap member comprises at least one of said one or more support members.

3. The apparatus of claim 1 wherein said end cap member comprises a support member formed in a circular shape of decreasing diameter.

4. The apparatus of claim 1 wherein said end cap member comprises a plurality of interwoven support members forming a fenestrated end cap.

5. The apparatus of claim 1 wherein said reactive material is applied to said end cap member.

6. The apparatus of claim 1 wherein said end cap member comprises a porous material

7. The apparatus of claim 1, wherein said end cap is capable of increasing the resistance of blood flow therethrough.

8. The apparatus of claim 1 wherein said end cap member comprises one or more filamentary elements.

9. The apparatus of claim 8 wherein said filamentary elements are arranged to form an end cap member selected from the group consisting of a coil, a weave, a braid, a mesh, a screen, and a cable.

10. The apparatus of claim 1 wherein said reactive material is a hydrogel.

11. The apparatus of claim 1 wherein said reactive material in configured to expand in response to changes in physiological pH.

12. The apparatus of claim 1 wherein said end cap member comprises a mesh member comprised of a plurality of wires.

13. The apparatus of claim 12 wherein said mesh member is comprised of fine, self-expanding wires.

14. The apparatus of claim 12 wherein said mesh member is a low porosity mesh member.

15. The apparatus of claim 14 wherein said low porosity member is a non-porous barrier.

16. The apparatus of claim 1 wherein said end cap has an extension along said longitudinal axis of said device that is less than said end cap diameter.

17. The apparatus of claim 1 wherein said end cap has an extension along said longitudinal axis of said device that is less than two times said end cap diameter.

18. The apparatus of claim 1, wherein said support device is substantially cylindrical and said support device comprises one or more support members along said longitudinal axis and defining fenestrations through said support device.

19. The apparatus of claim 18 wherein said end cap member comprises a plurality of said one or more support members interwoven together.

20. The apparatus of claim 1 wherein said anchoring member is a stent.

21. The apparatus of claim 20 wherein said stent is comprised of support members defining fenestrations through said support device.

22. The apparatus of claim 1 further comprising a plurality of elongated members along said longitudinal axis and connecting said end cap member to said anchoring member.

23. The apparatus of claim 22 wherein said end cap member is comprised of self-expanding end cap member wires and said elongated members comprise the same self-expanding material as said end cap member and said elongated members comprise wires of the same size as said end cap member wires.

24. The apparatus of claim 23 wherein said elongated members are extensions of said end cap member wires.

25. The apparatus of claim 23 wherein said elongated members are attached to said end cap member.

26. The apparatus of claim 23 wherein said anchoring member is comprised of the same self-expanding material as said end cap member and said elongated members.

27. The apparatus of claim 23 wherein said elongated members are an extension of said anchoring member.

28. An apparatus for treating vascular aneurysms, comprising:

an occlusive support device comprising a longitudinal axis having first end portion and a second end portion;

an end cap member at said first end portion of said occlusive support device, wherein said end cap member has an end cap diameter and said end cap is generally perpendicular to said longitudinal axis of said support device, wherein said end cap has an extension along said longitudinal axis of said device that is less than two times said end cap diameter and wherein said end cap member has openings and said end cap member comprises a reactive material that is configured to hydrate upon delivery of the device and to reduce the size of said openings; and

an anchoring member at said second end portion.

29. The apparatus of claim 28 wherein said reactive material in configured to expand in response to changes in physiological pH.

30. An apparatus for treating vascular aneurysms, comprising:

an occlusive support device comprising one or more support members forming a first end portion and a second end portion and defining a lumen therethrough; and

a mesh end cap member at said first end portion of said occlusive support device, said mesh end cap member comprised of at least one of said one or more support members;

wherein said end cap member has openings and said end cap member comprises a reactive material that is configured to hydrate upon delivery of the device and to reduce the size of said openings; and

an anchoring member at said second end portion.

31. The apparatus of claim 30 wherein said reactive material in configured to expand in response to changes in physiological pH.

32. A method of treating a vascular aneurysm, comprising:

providing a device having an occlusive member at a first end portion and an anchoring member at a second end portion wherein said occlusive member is provided with reactive material and said reactive material reacts with blood so as to increase the resistance to blood flow into the aneurysm;

positioning the device in the blood vessel so that the occlusive member is proximate the neck of a vascular aneurysm and permitting the reactive material to react with the blood so as to reduce the flow of blood into the aneurysm; and

deploying the anchoring member in the blood vessel so that that anchoring member anchors the device in the blood vessel without occluding flow through the blood vessel.

33. The method of claim 32 further comprising the step of deploying embolic or space-filling material into the aneurysm.

34. The method of claim 33 wherein said step of deploying embolic material takes place before said occlusive members is positioned proximate the neck of the aneurysm.

35. The method of claim 33 wherein said step of deploying embolic material takes place after said occlusive members is positioned proximate the neck of the aneurysm.

36. The method of claim 32 wherein said reactive material is a hydrogel.

37. The method of claim 32 wherein said reactive material is configured to expand in response to changes in physiological pH.

38. The method of claim 32 wherein said reactive material is chemically doped or impregnated with a material used to promote endothelial cellular adhesion.