Method and apparatus for severing organic molecules by ultrasound
First Claim
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1. An apparatus for manipulating a liquid sample stored in at least one well of a well plate, the apparatus comprising:
- a. a lid having an upper side and a lower side, said lower side of said lid engaging the well plate;
b. at least one pin having an upper end and a lower end, said upper end of said at least one pin penetrating said upper side of said lid, said lower end of said at least one pin extending through said lid into the at least one well of the well plate, c. means to transfer energy to or from said upper end of said at least one pin, said at least one pin transferring said energy to or from the liquid sample.
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Abstract
A lid for a well plate is provided. Pins penetrate the lid and project downwardly into the wells of the well plate. Thermal energy is applied to the upper end of the pin to regulate the temperature of liquid samples in the well plate. Ultrasonic energy is applied to the upper end of the pin to sonicate the liquid sample. An electrical charge is applied to the upper end of the pin to attract charged materials, such as DNA, and to selectably segregate charged materials from the liquid sample.
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Citations
18 Claims
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1. An apparatus for manipulating a liquid sample stored in at least one well of a well plate, the apparatus comprising:
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a. a lid having an upper side and a lower side, said lower side of said lid engaging the well plate;
b. at least one pin having an upper end and a lower end, said upper end of said at least one pin penetrating said upper side of said lid, said lower end of said at least one pin extending through said lid into the at least one well of the well plate, c. means to transfer energy to or from said upper end of said at least one pin, said at least one pin transferring said energy to or from the liquid sample. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
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14. A method for manipulating a liquid sample in a well of a well plate comprising the steps of:
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a. placing the liquid sample in the well of the well plate;
b. placing a lid on the well plate, said lid having an upper side and a lower side, said lid having at least one pin having an upper end and a lower end, said pin penetrating said lid, said upper end of said pin extending to said upper side of said lid, said lower end of said pin extending into the well of the well plate, said lower end of said pin physically contacting the liquid sample;
c. applying sonic energy to said upper end of said at least one pin, said pin transmitting said sonic energy to said lower end of said at least one pin. - View Dependent Claims (15, 16, 17, 18)
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Specification