Targeted delivery of controlled release polymer systems
First Claim
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1. A conjugate, comprising a nucleic acid ligand bound to a controlled release polymer system.
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Abstract
The present invention relates to a conjugate that includes a nucleic acid ligand bound to a controlled release polymer system, a pharmaceutical composition that contains the conjugate, and methods of treatment using the conjugate. The controlled release polymer system includes an agent such as a therapeutic, diagnostic, prognostic, or prophylactic agent. The nucleic acid ligand that is bound to the controlled release polymer system, binds selectively to a target, such as a cell surface antigen, and thereby delivers the controlled release polymer system to the target.
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91 Claims
- 1. A conjugate, comprising a nucleic acid ligand bound to a controlled release polymer system.
- 34. A method of delivering an agent to a target cell, comprising contacting the target cell with a conjugate comprising a nucleic acid ligand bound to a controlled release polymer system that comprises the agent, wherein the nucleic acid ligand selectively binds to the target cell.
- 63. A method of diagnosing, predicting the outcome, or treating a patient with cancer, comprising administering to the patient a conjugate comprising a nucleic acid ligand bound to a controlled release polymer system, wherein the nucleic acid ligand selectively binds to tumor cells.
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