Method for applying drug coating to a medical device in surgeon room
First Claim
1. A method for coating a medical device at a clinical site just prior to use of the medical device on the patient, the method comprising the steps of:
- (a) preparing an aqueous latex polymeric emulsion;
(b) dipping a medical device in the aqueous latex polymeric emulsion;
(c) drying the aqueous latex polymeric emulsion on the medical device to form a coating thereon;
(d) repeating steps (b) and (c) until the aqueous latex polymeric emulsion coating reaches a predetermined thickness; and
(e) using the coated medical device in a therapeutic procedure on a patient at the clinical site immediately after performing step (d).
2 Assignments
0 Petitions
Accused Products
Abstract
Medical devices, and in particular implantable medical devices such as stents and stent delivery systems including catheters, may be coated to minimize or substantially eliminate a biological organism'"'"'s reaction to the introduction of the medical device to the organism or to treat a particular condition. A dip coating process is utilized to minimize waste and to customize coating thickness and drug loading directly at the clinical site just prior to therapeutic use on a patient. An aqueous latex polymeric emulsion is utilized to coat any medical device to a desired thickness by allowing for successive dipping and drying cycles at the clinical site. In addition, aqueous latex polymeric emulsions pose less of a chance of the bridging phenomenon associated with organic solvent based polymers.
45 Citations
48 Claims
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1. A method for coating a medical device at a clinical site just prior to use of the medical device on the patient, the method comprising the steps of:
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(a) preparing an aqueous latex polymeric emulsion;
(b) dipping a medical device in the aqueous latex polymeric emulsion;
(c) drying the aqueous latex polymeric emulsion on the medical device to form a coating thereon;
(d) repeating steps (b) and (c) until the aqueous latex polymeric emulsion coating reaches a predetermined thickness; and
(e) using the coated medical device in a therapeutic procedure on a patient at the clinical site immediately after performing step (d). - View Dependent Claims (2, 3, 4, 5)
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6. A method for coating a medical device at a clinical site just prior to use of the medical device on a patient, the method comprising the steps of:
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(a) preparing an aqueous latex polymeric emulsion;
(b) adding at least one drug, agent and/or compound, in therapeutic dosages, to the aqueous latex polymeric emulsion for the treatment of a predetermined condition;
(c) dipping the medical device in the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound;
(d) drying the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound, on the medical device to form a coating thereon;
(e) repeating steps (c) and (d) until the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound coating reaches a predetermined thickness; and
(f) using the coated medical device in a therapeutic procedure on a patient at the clinical site immediately after performing step (e). - View Dependent Claims (7, 8, 9, 10, 11, 12)
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13. A method for coating a stent at a clinical site just prior to use of the stent on a patient, the method comprising the steps of:
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(a) preparing an aqueous latex polymeric emulsion;
(b) dipping the stent in the aqueous latex polymeric emulsion;
(c) drying the aqueous latex polymeric emulsion on the stent to form a coating thereon;
(d) repeating steps (b) and (c) until the aqueous latex polymeric emulsion coating reaches a predetermined thickness; and
(e) using the coated stent in a therapeutic procedure on a patient at the clinical site immediately after performing step (d). - View Dependent Claims (14, 15, 16, 17)
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18. A method for coating a stent at a clinical site just prior to use of the stent on a patient, the method comprising the steps of:
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(a) preparing an aqueous latex polymeric emulsion;
(b) adding at least one drug, agent and/or compound, in therapeutic dosages, to the aqueous latex polymeric emulsion for the treatment of a predetermined condition;
(c) dipping the stent in the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound;
(d) drying the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound, on the stent to form a coating thereon;
(e) repeating steps (c) and (d) until the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound coating reaches a predetermined thickness; and
(f) using the coated stent in a therapeutic procedure on a patient at the clinical site immediately after performing step (e). - View Dependent Claims (19, 20, 21, 22, 23, 24)
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25. A method for coating a stent delivery system at a clinical site just prior to use of the stent delivery system on a patient, the method comprising the steps of:
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(a) preparing an aqueous latex polymeric emulsion;
(b) dipping the stent delivery system in the aqueous latex polymeric emulsion;
(c) drying the aqueous latex polymeric emulsion on the stent delivery system to form a coating thereon;
(d) repeating steps (b) and (c) until the aqueous latex polymeric emulsion coating reaches a predetermined thickness; and
(e) using the coated stent delivery system in a therapeutic procedure on a patient at the clinical site immediately after performing step (d). - View Dependent Claims (26, 27, 28, 29)
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30. A method for coating a stent delivery system at a clinical site just prior to use of the stent delivery system on a patient, the method comprising the steps of:
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(a) preparing an aqueous latex polymeric emulsion;
(b) adding at least one drug, agent and/or compound, in therapeutic dosages, to the aqueous latex polymeric emulsion for the treatment of a predetermined condition;
(c) dipping the stent delivery system in the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound;
(d) drying the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound, on the stent delivery system to form a coating thereon;
(e) repeating steps (c) and (d) until the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound coating reaches a predetermined thickness; and
(f) using the coated stent delivery system in a therapeutic procedure on a patient at the clinical site immediately after performing step (e). - View Dependent Claims (31, 32, 33, 34, 35, 36)
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37. A method for coating a catheter at a clinical site just prior to use of the catheter on a patient, the method comprising the steps of:
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(a) preparing an aqueous latex polymeric emulsion;
(b) dipping the catheter in the aqueous latex polymeric emulsion;
(c) drying the aqueous latex polymeric emulsion on the catheter to form a coating thereon;
(d) repeating steps (b) and (c) until the aqueous latex polymeric emulsion coating reaches a predetermined thickness; and
(e) using the coated catheter in a therapeutic procedure on a patient at the clinical site immediately after performing step (d). - View Dependent Claims (38, 39, 40, 41)
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42. A method for coating a catheter at a clinical site just prior to use of the catheter on a patient, the method comprising the steps of:
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(a) preparing an aqueous latex polymeric emulsion;
(b) adding at least one drug, agent and/or compound, in therapeutic dosages, to the aqueous latex polymeric emulsion for the treatment of a predetermined condition;
(c) dipping the catheter in the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound;
(d) drying the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound, on the catheter to form a coating thereon;
(e) repeating steps (c) and (d) until the aqueous latex polymeric emulsion, including the at least one drug, agent and/or compound coating reaches a predetermined thickness; and
(f) using the coated catheter in a therapeutic procedure on a patient at the clinical site immediately after performing step (e). - View Dependent Claims (43, 44, 45, 46, 47, 48)
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Specification