Silver-containing wound care device

• US 20050037680A1
• Filed: 08/14/2003
• Published: 02/17/2005
• Est. Priority Date: 08/14/2003
• Status: Active Grant

• Current Assignee: Milliken & Company
• Original Assignee: Milliken & Company
• Inventors: Canada, T. Andrew, Wiencek, Kenneth M., Sturm, Raymond C., Schuette, Robert L.
• Granted Patent: US 8,563,447 B2
• Time in Patent Office: Days
• US Class Current: 442/59
• CPC Class Codes: A61K 33/38 Silver; Compounds thereof
• CPC Class Codes: A61L 15/18 containing inorganic materials
• CPC Class Codes: A61L 15/44 Medicaments
• CPC Class Codes: A61L 15/46 Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
• CPC Class Codes: Y10T 442/20 Coated or impregnated woven, knit, or nonwoven fabric which is not [a] associated with another preformed layer or fiber layer or, [b] with respect to woven and knit, characterized, respectively, by a particular or differential weave or knit, wherein the coating or impregnation is neither a foamed material nor a free metal or alloy layer
• CPC Class Codes: Y10T 442/2525 Coating or impregnation functions biologically [e.g., insect repellent, antiseptic, insecticide, bactericide, etc.]

Abstract

Wound care devices having a topically applied silver-based antimicrobial finish are provided. The finish comprises at least one silver ion-containing compound and at least one binder compound. The finish may be applied to a target substrate, such as a fiber, fabric, film, foam, hydrogen, or hydrocolloid to provide a single layer antimicrobial wound care device. Alternatively, a silver-containing layer may be combined with one or more additional layers of target substrate to provide a composite antimicrobial wound care device. The device may also contain an odor-absorbing component capable of reducing or eliminating odors that are inherently associated with infectious wounds. Also provided is a method for making the wound care device and a composition of matter comprising the silver-based antimicrobial finish.

Claims

1. A wound care device having a surface, at least a portion of which is coated with a non-electrically conductive finish,

wherein said finish comprises at least one compound delivering silver ions and at least one binder material;

and

wherein said coated wound care device exhibits a controlled silver-ion release rate of less than about 50 μ

g/cm² of silver ions over a 24 hour period, and wherein said finish exhibits antimicrobial properties.

2. The coated wound care device of claim 1, wherein said coated wound care device exhibits a controlled silver-ion release rate of less than about 25 μ

g/cm² of silver ion over a 24 hour period.

3. The coated wound care device of claim 1, wherein said coated wound care device exhibits a controlled silver-ion release rate of less than about 10 μ

g/cm² of silver ion over a 24 hour period.

4. The coated wound care device of claim 1, wherein said at least one compound delivering silver ions is selected from the group consisting of ion exchange materials such as silver zirconium phosphate, silver calcium phosphate, silver zeolite, silver glass, and any mixtures thereof.

5. The coated wound care device of claim 4, wherein said at least one compound delivering silver ions is silver zirconium phosphate.

6. The wound care device of claim 1, wherein said coated wound care device if free from discoloration, wherein said discoloration is due to chemical instability of said non-electrically conductive finish.

7. The coated wound care device of claim 1, wherein said coated wound care device includes an odor absorbing agent.

8. The coated wound care device of claim 7, wherein said odor absorbing agent is selected from the group consisting of activated carbon, charcoal, and zeolite.

9. The coated wound care device of claim 1, wherein said coated wound care device is comprised of one or more substrates selected from the group consisting of fibers, fabrics, films, foams, alginates, hydrogels, and hydrocolloids.

10. The coated wound care device of claim 9, wherein said fabrics includes woven, nonwoven, and knit fabrics.

11. The coated wound care device of claim 10, wherein said coated wound care device is a nonwoven fabric comprised of continuous composite filaments, each of said composite filaments comprising at least a first filament material and a second filament material that are at least partially longitudinally separated into elementary filaments of said first filament material and said second filament material.

12. The coated wound care device of claim 11, wherein said continuous composite filaments are microdenier.

13. The coated wound care device of claim 11, wherein said nonwoven fabric is a hydroentangled web.

14. The coated wound care device of claim 13, wherein said nonwoven fabric is a hydroentangled web that has been thermally bonded.

15. The coated wound care device of claim 11, wherein said first filament material is a polyester material selected from the group consisting of polyethylene terephthalate (PET), polybutylene terephthalate (PBT), polytrimethylene terephthalate (PTT), and polylactic acid (PLA).

16. The coated wound care device of claim 15, wherein said first filament material is PET.

17. The coated wound care device of claim 11, wherein said second filament material is a polyamide selected from the group consisting of nylon 6, nylon 66, nylon 11, and nylon 610.

18. The coated wound care device of claim 17, wherein said second filament material is nylon 6.

19. The coated wound care device of claim 11, wherein said first filament material is PET and said second filament material is nylon 6.

20. The coated wound care device of claim 19 wherein said coated wound care device has an absorption capacity rate that is at least 80% of the absorption capacity of said wound care device having no coating.

21. The coated wound care device of claim 19, wherein said coated wound care device has a moisture vapor transmission rate that is at least 85% of said wound care device having no coating.

22. The coated wound care device of claim 19, wherein said coated wound care device exhibits a log kill rate for Staphylococcus aurous after a 22-hour exposure in accordance with AATCC Method 100-1999 of at least 2.07.

23. The coated wound care device of claim 19, wherein said coated wound care device exhibits a log kill rate for Pseudomonas aeruginosa after a 22-hour exposure in accordance with AATCC Method 100-1999 of at least 1.49.

24. The coated wound care device of claim 9, wherein said coated wound care device is a foam.

25. The coated wound care device of claim 24, wherein said coated wound care device is a foam selected from the group consisting of polyurethane, carboxylated butadiene styrene rubber, polyester, and polyacrylate.

26. The coated wound care device of claim 25, wherein said coated wound care device is a polyurethane foam.

27. A wound care device having a surface, at least a portion of which is coated with a non-electrically conductive finish,

wherein said finish comprises at least one compound delivering silver ions and at least one binder material;

and

wherein said coated wound care device exhibits a controlled silver-ion release rate of less than about 25 μ

g/cm² of silver ions over a 24 hour period, and wherein said finish exhibits antimicrobial properties.

28. A microdenier nonwoven wound care device having a surface, at least a portion of which is coated with a non-electrically conductive finish,

wherein said finish comprises at least one compound delivering silver and at least one binder material;

and

wherein said coated wound care device exhibits a controlled silver-ion release rate of less than about 50 μ

g/cm² of silver ions over a 24 hour period, and wherein said finish exhibits antimicrobial properties.