Compositions and methods for the treatment of depression and other affective disorders
First Claim
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1. A method for the treatment or alleviation of depression or other affective disorders comprising administering an amount of an anti-inflammatory agent effective to treat or alleviate depression or other affective disorder to a subject in need thereof.
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Abstract
The present invention relates to compositions and methods for treating depression. The compositions and methods comprise the use of anti-inflammatory compounds alone or in combination with antidepressant compounds to down regulate HPA activation through the targeting of peripheral (non-CNS) cytokines.
63 Citations
35 Claims
- 1. A method for the treatment or alleviation of depression or other affective disorders comprising administering an amount of an anti-inflammatory agent effective to treat or alleviate depression or other affective disorder to a subject in need thereof.
- 16. A method for the treatment of depression or other affective disorder comprising administering an effective amount of an anti-inflammatory agent to a subject in need thereof, wherein said anti-inflammatory agent down-regulates peripheral serum levels of a pro-inflammatory molecule or up-regulates peripheral serum levels of an anti-inflammatory molecule or both.
- 19. A method for potentiating the action of an antidepressant agent comprising administering an effective amount of a combination of agents to a subject in need thereof, wherein said combination comprises an effective amount an antidepressant agent and an amount of an anti-inflammatory agent effective to treat or alleviate depression or other affective disorder.
- 23. A method for the treatment or prevention of drug induced depression comprising administering an amount of an anti-inflammatory agent effective to treat or alleviate depression to a subject in need thereof.
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31. A method for the identification of an anti-inflammatory agent for use in the treatment of depression and affective disorders which comprises:
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(a) inducing pro-inflammatory cytokines in a test animal;
(b) administering a test agent to the test animal;
(c) obtaining a blood sample from the test animal;
(d) assaying the blood sample;
(e) determining the levels of IL-1, IL-6 and TNF in said blood; and
(f) identifying a compound that down regulates pro-inflammatory cytokine production. - View Dependent Claims (32, 33, 34, 35)
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Specification