Method and apparatus for the treatment of obesity
First Claim
1. A method of modulating satiety in a subject, the method comprising:
- implanting in a subject, at an implantation site, an active agent delivery system comprising a pump and a formulation, the formulation comprising an active agent selected from the group consisting of nutrients and pharmacological agents, wherein the formulation comprises a therapeutically effective amount of the active agent sufficient for inducing or promoting a feeling of satiety in the subject, and delivering the formulation from the active agent delivery system to the subject whereby the active agent enters the gastrointestinal system, whereby the active agent is present at the site of action within the gastrointestinal tract in an amount sufficient to modulate satiety.
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Abstract
The present invention includes methods and materials for manipulating the sense of satiety developed from the gastrointestinal transit of a substance in a mammal, whether the substance be a food or drug compound. The method involves administering a therapeutically effective amount, by a direct delivery route, of a pharmaceutically acceptable formulation comprising nutrients and pharmacological agents to the mammal'"'"'s gastrointestinal tract. The present system is designed to maximize satiety feedback from normal intestinal sensors by small amounts of nutrients or nutrient derivatives, in essence, to “fool” body sensors that are not usually in contact with nutrients unless very large amounts are ingested.
229 Citations
40 Claims
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1. A method of modulating satiety in a subject, the method comprising:
implanting in a subject, at an implantation site, an active agent delivery system comprising a pump and a formulation, the formulation comprising an active agent selected from the group consisting of nutrients and pharmacological agents, wherein the formulation comprises a therapeutically effective amount of the active agent sufficient for inducing or promoting a feeling of satiety in the subject, and delivering the formulation from the active agent delivery system to the subject whereby the active agent enters the gastrointestinal system, whereby the active agent is present at the site of action within the gastrointestinal tract in an amount sufficient to modulate satiety. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30)
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31. A device for the modulating satiety in a subject, comprising:
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a controlled active agent delivery system adapted for complete implantation at an implantation site in a subject, the device comprising a pump and a formulation comprising an active agent selected from the group consisting of nutrients and pharmacological agents, wherein the implantation site is selected from the group consisting of a subcutaneous site, an intraperitoneal site, a subdermal site, an intramuscular site, and an intra-adipose tissue site, and wherein the formulation comprises therapeutically effective amount of the active agent sufficient for inducing or promoting a feeling of satiety in the subject for a period of at least about 3 days;
wherein the implantable device is adapted for intestinal delivery of the formulation to a site of action in the subject, whereby the active agent is present at the site of action within the gastrointestinal tract in an amount sufficient to modulate satiety. - View Dependent Claims (32, 33, 34, 35, 36, 37, 38, 39, 40)
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Specification