Reduction of matrix interference for MALDI mass spectrometry analysis
First Claim
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1. A sample plate for MALDI analysis comprising:
- an electrically conductive substrate having a first surface, at least a portion of the first surface coated with a composite coating that comprises a hydrophobic coating and a coating of a thin film mixture of a matrix and an intercalating polymer.
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Abstract
A MALDI plate suitable for MS or MS-MS analysis provided with a composite coating that comprises a hydrophobic coating and a thin layer coating of a mixture of a MALDI matrix material and an intercalating agent such as a polymer is disclosed. A MALDI plate produced in accordance with the present teachings is useful for suppression of matrix ions in the low mass region (<1,000 daltons) of a MALDI-MS spectrum.
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Citations
12 Claims
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1. A sample plate for MALDI analysis comprising:
an electrically conductive substrate having a first surface, at least a portion of the first surface coated with a composite coating that comprises a hydrophobic coating and a coating of a thin film mixture of a matrix and an intercalating polymer. - View Dependent Claims (2, 3, 4, 5, 6)
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7. The process for making a sample plate for MALDI MS or MS-MS analysis comprising:
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forming a hydrophobic coating on a first surface of an electrically conductive substrate; and
forming a second coating on the first surface and the hydrophobic coating with a mixture in solution containing a matrix and an intercalating polymer to form a composite coating on the substrate, - View Dependent Claims (8, 9, 10, 11, 12)
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Specification