Molecular electronic component used to construct nanoelectronic circuits, molecular electronic component, electronic circuit and method for producing the same

• US 20050041458A1
• Filed: 11/08/2002
• Published: 02/24/2005
• Est. Priority Date: 11/09/2001
• Status: Abandoned Application

• Current Assignee: Harald Lossau
• Original Assignee: Harald Lossau
• Inventors: Lossau, Harald, Hartwich, Gerhard
• Application Number:
  US10/494,745
• Publication Number:
  US 20050041458A1
• Time in Patent Office: Days
• US Class Current: 365/151
• CPC Class Codes: B82Y 10/00 Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
• CPC Class Codes: G11C 13/0014 comprising cells based on organic memory material
• CPC Class Codes: G11C 13/0019 comprising bio-molecules
• CPC Class Codes: H10K 10/701 Organic molecular electronic devices
• CPC Class Codes: H10K 30/00 Organic devices sensitive to infrared radiation, light, electromagnetic radiation of shorter wavelength or corpuscular radiation integrated devices or assemblies of multiple devices H10K39/00, H10K65/00; electrolytic light-sensitive devices H01G9/20
• CPC Class Codes: H10K 39/00 Integrated devices, or assemblies of multiple devices, comprising at least one organic radiation-sensitive element covered by group H10K30/00
• CPC Class Codes: H10K 50/11 characterised by the electroluminescent [EL] layers
• CPC Class Codes: H10K 59/00 Integrated devices, or assemblies of multiple devices, comprising at least one organic light-emitting element covered by group H10K50/00
• CPC Class Codes: H10K 85/761 Biomolecules or bio-macromolecules, e.g. proteins, chlorophyl, lipids or enzymes

Abstract

A molecular electronic device for constructing nanoelectronic circuits comprises a redox-active moiety having an electron donor (D) and an electron acceptor (A), the electron donor and the electron acceptor (A) having a respective contact spot (K1, K2) for forming connections with other devices, and the contact spots (K1, K2) facilitating charge transport to the device and away from the device. In particular, the respective contact spot (K1, K2) of electron donor (D) and electron acceptor (A) is a permanent contact spot for mediating the charge transport across a permanent chemical bond, the contact spot respectively comprising one of the binding partners of the chemical bond. Multiple such devices can be combined via the contact spots to form a module or an electronic circuit.

Claims

1. A molecular electronic device for constructing nanoelectronic circuits, having a redox-active moiety having an electron donor (D) and an electron acceptor (A), the electron donor and the electron acceptor (A) having a respective contact spot (K1, K2) for forming connections with other devices, and the contact spots (K 1, K2) facilitating charge transport to the device and away from the device,

wherein the respective contact spot (K 1, K2) of electron donor (D) and electron acceptor (A) is a permanent contact spot for mediating the charge transport across a permanent chemical bond, the contact spot respectively comprising one of the binding partners of the chemical bond-. and wherein the permanent contact spots are adapted to forming a nucleic acid interaction a stable interaction between proteins, or an antigen-antibody interaction.

5. The device according to claim 1 or 2, wherein the redox-active moiety additionally comprises one or more macromolecules, especially further electron-donor and electron-acceptor molecules.

6. The device according to claim 1 or 2, wherein the redox-active moiety is the native or modified reaction center of photosynthesizing organisms, especially the native or modified reaction center of photosynthesizing bacteria.

7. The device according to claim 1 or 2, wherein the electron donor (D) and electron acceptor (A) are part of a donor-acceptor complex, especially a pigment-protein complex, of the reaction center of Rhodopseudomonas viridis, of the reaction center of Rhodobacter sphaeroides, of the reaction center of thermophilic bacteria, or of Chloroflexus aurantiacus.

8. The device according to claim 1 or 2, wherein the electron donor (D) and/or the electron acceptor (A) are dyes, especially flavins, (metallo)porphyrins, (metallo)chlorophylls, or (metallo)bacteriochlorophylls, or derivatives thereof.

9. The device according to claim 1 or 2, wherein the electron donor (D) and/or the electron acceptor (A) are nicotinamides or quinones, especially pyrrolo-quinoline quinones (PQQ), 1,2-benzoquinones, 1,4-benzoquinones, 1,2-naphtoquinones, 1,4-naphtoquinones, or 9,10-anthraquinones, or derivatives thereof.

10. The device according to claim 1 or 2, wherein the electron donor (D) and/or the electron acceptor (A) are charge-transfer complexes.

11. The device according to claim 10, wherein the charge-transfer complex is a transition metal complex, especially an Ru(II), a Cr(III), an Fe(II), an Os(II), or a Co(II) complex.

12. The device according to claim 1 or 2, wherein the electron donor (D) is selected from the group fullerene, especially C60, p-doped fullerene, and carotenoid.

13. The device according to claim 1 or 2, wherein the electron acceptor (A) is selected from the group fullerene, especially C60, n-doped fullerene, and stilbene.

14. The device according to claim 1 or 2, wherein the binding partner of the chemical bond of the permanent contact spot(s) is selected from the group consisting of amino groups and groups that can be specifically linked therewith, especially carboxy and hydroxyl groups, activated esters, especially succinimidyl esters, isothiocyanates, sulfonyl chlorides, and aldhehydes—

thiol groups and groups that can be specifically linked therewith, especially alkyl halides, haloacetamides, maleimides, aziridines, and symmetrical disulfides—

hydroxyl groups and groups that can be specifically linked therewith, especially acyl azides, isocyanates, acyl nitriles, and acyl chlorides—

aldehydes, ketones, and groups that can be specifically linked therewith—

especially hydrazines and aromatic amines.

15. The device according to claim 14, wherein at least one of the binding partners of the chemical bond is provided with a protective group to prevent the forming of a connection.

16. The device according to claim 1 or 2, wherein the binding partner of the chemical bond of the permanent contact spot(s) is a single-stranded nucleic acid oligomer having a specific sequence, preferably DNA, RNA, or PNA oligonucleotide consisting of 5 to 30 nucleotides.

17. The device according to claim 1 or 2, wherein the binding partner of the chemical bond of the permanent contact spot(s) is a photoactivatable crosslinker, such as aryl azide or a benzophenone derivative.

18. The device according to claim 1 or 2, the surface of which, with the exception of the contact spots, is electrically insulating.

19. The device according to claim 18, on the surface of which, with the exception of the contact spots, electrically insulating molecular moieties are arranged, preferably molecular moieties selected from the group of peptides, proteins, and cyclodextrins.

20. The device according to claim 1 or 2, wherein a charge transfer between the electron donor (D) and the electron acceptor (A) is variable through external influences, especially through electromagnetic radiation, temperature, static electric or magnetic fields, pressure, acceleration, or a chemical environment.

21. The device according to claim 1 or 2, that includes, in addition to the electron donor (D) and the electron acceptor (A), at least a further redox-active substance, the further redox-active substance having a contact spot formed as a permanent or temporary contact spot for forming a connection with other devices.

22. The device according to claim 21, wherein the further redox-active substance is arranged such that its electrical potential influences the charge transfer between the electron donor (D) and the electron acceptor (A), especially wherein the charge-carrier transfer rate increases the higher the potential of the further redox-active substance lies, or wherein the charge-carrier transfer rate decreases the higher the potential of the further redox-active substance lies.

23. A molecular electronic module comprising two or more devices (10,20,30) according to claim 1 or 2, connected via contact spots (SC, SC, SR, SR).

24. The module according to claim 23, wherein part (SC, SC, SR, SR) of the permanent contact spots (SI,SG,SC, SC,SO,SR, SR,SS) of the devices carries corresponding binding partners, and at least part of the devices are joined together through a chemical reaction between corresponding binding partners.

25. The module according to claim 23, wherein at least part of the devices are electrically connected via linear molecules of defined conductivity arranged between their contact spots and provided with permanent contact spots at both ends.

26. The module according to claim 25, wherein the linear binding molecules are selected from the group consisting of linear, unsaturated hydrocarbons, especially polyacetylenes (CH)_x, carbynes C_x, sulfur-nitrogen polymers (SN)_x, polypyrroles, and phenylacetylenes (oligo-phenylethynyls), double-stranded nucleic acid oligomers, especially DNA, RNA, or PNA, biological nerve cells, carbon nanotubes, silicon nanowires, conductive organic crystals, such as fluoranthene hexafluorophoshate and perylene hexafluorophoshate, and other radical cation salts of the arenes.

27. The module according to claim 25, wherein at least one of the linear binding molecules consists substantially of unsaturated hydrocarbons, and the electrical resistance of which is increased by incorporating individual saturated carbon atoms.

28. The module according to claim 25, wherein at least one of the linear binding molecules consists substantially of double-stranded nucleic acid oligomers, and the electrical resistance of which is increased by incorporating base mismatches or sections of single-stranded nucleic acid oligomers.

29. The module according to claim 25, wherein at least one of the linear binding molecules is formed by a doped carbon nanotube, the conductivity of which is changed by incorporating foreign atoms.

30. The module according to claim 23, that electrically forms an AND, OR, NAND, NOR, or EXOR gate, a memory element, especially an ROM or SRAM, an amplifier, or a sensor.

31. An electronic circuit having at least one molecular device according to claim 1 or 2, or a molecular electronic module according to claim 23,

wherein at least one device (10, 20, 30) is attached to an electrically conducting surface (111), especially through covalent attachment or specific adsorption.

32. A method for producing an electronic circuit, wherein in solution

at least one first component part is added, wherein a component part comprises

a device according to claim 1 or 2 or a molecular electronic device with a redox-active moiety having an electron donor (D) and an electron acceptor (A), the electron donor and the electron acceptor (A) having a respective contact spot (K1, K2) for forming connections with other devices, and the contact spots (K1, K2) facilitating charge transport to the device and away from the device, wherein the respective contact spot (K1 K2) of electron donor (D) and electron acceptor (A) is a permanent contact spot for mediating the charge transport across a permanent chemical bond, the contact spot respectively comprising one of the binding partners of the chemical bond,

a molecular electronic module according to claim 23, or

a conductive linear connection molecule,

at least one further component part is added,

the first and the further component part having a respective permanent contact spot with corresponding binding partners, such that the first and the further component part connect in the solution at the corresponding contact spots,

the step of adding further components part is repeated,

the further component part and one of the already connected component parts having a respective permanent contact spot with corresponding binding partners, such that the component parts connect in the solution at the corresponding contact spots until a number of predetermined component parts is connected, and

the connected component parts are applied to a conductive surface.

34. The method for producing an electronic circuit according to claim 32, wherein, prior to a step of adding a further component part, a protective group attached to a permanent contact spot of a component part in the solution is deprotected, especially removed.

36. An electronic circuit obtainable by the method of claims 32 or 33.

2. A molecular electronic device for constructing nanoelectronic circuits, having a redox-active moiety having an electron donor (D) and an electron acceptor (A), the electron donor (D) and the electron acceptor (A) having a respective contact spot (K1, K2) for forming connections with other devices, and the contact spots (K1, K2) facilitating charge transport to the device and away from the device,

wherein a first one of the contact spots (FIG. 3a:

K2) of electron donor (D) and electron acceptor (A) is a permanent contact spot for mediating the charge transport across a permanent chemical bond, the first contact spot comprising one of the binding partners of the chemical bond, and wherein a second one of the contact spots (FIG. 3a;

K1) of electron donor (D) and electron acceptor (A) is a temporary contact spot for mediating the charge transport without permanently attaching a substance to the contact spot.

3. The device according to claim 2, wherein the temporary contact spot (FIG. 3a:

K1) is adapted to labile interactions between proteins or as a docking spot for redox-active substances.

4. The device according to claim 2, wherein the permanent contact spot or the permanent contact spots are adapted to forming a covalent bond or a permanent ligate-ligand interaction, especially a nucleic acid interaction, a stable interaction between proteins, an antigen-antibody interaction, or an ion-ligand interaction.

33. A method for producing an electronic circuit, wherein

a conductive surface is provided, and in solution

at least one first component part is added and connected to the conductive surface,

at least one further component part is added,

the first and the further component part having a respective permanent contact spot with mutually assigned binding partners, such that the first and the further component part connect in the solution at the corresponding contact spots,

the step of adding further component parts is repeated,

the further component part and one of the already connected component parts having a respective permanent contact spot with corresponding binding partners, such that the component parts connect in the solution at the corresponding contact spots, until a number of predetermined component parts is connected.

35. The method for producing an electronic circuit according to claim 33, wherein, prior to a step of adding a further component part, a protective group attached to a permanent contact spot of a component part connected to the surface is deprotected, especially removed.