Tissue repair and replacement
First Claim
1. A device for tissue repair or replacement, comprising first and second components having different relative rates of in vivo degradation, the first component having a higher rate of in vivo degradation than the second component, and the first and second components being arranged relative to each other so that, after implantation of the device, the first component degrades in vivo leaving a scaffold formed of the second component, the scaffold having pores into which tissue can infiltrate.
1 Assignment
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Accused Products
Abstract
Tissue fixation devices are provided. The devices include a first component and a second component, the components having different rates of in vivo degradation. The first component and second component are arranged so that, upon degradation of one of the components, the other component provides a scaffold into which bone can grow.
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Citations
48 Claims
- 1. A device for tissue repair or replacement, comprising first and second components having different relative rates of in vivo degradation, the first component having a higher rate of in vivo degradation than the second component, and the first and second components being arranged relative to each other so that, after implantation of the device, the first component degrades in vivo leaving a scaffold formed of the second component, the scaffold having pores into which tissue can infiltrate.
- 12. A device for tissue repair or replacement, comprising a blend of two immiscible polymers having different rates of in vivo degradation, the blend having a substantially co-continuous macroscopic phase-separated structure.
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19. A device for tissue repair or replacement, comprising a blend of two immiscible polymers having different rates of in vivo degradation, the device being substantially non-porous prior to implantation in a patient.
- 22. A tissue fixation device comprising a porous ceramic structure and a polymer disposed in pores of the ceramic structure, the device being substantially non-porous prior to implantation in a patient.
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33. A device for tissue repair or replacement, comprising:
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a porous ceramic structure comprising a first ceramic; and
a second ceramic disposed in pores of the ceramic structure, the device being substantially non-porous prior to implantation in a patient. - View Dependent Claims (34, 35, 36)
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37. A method of tissue repair or replacement, comprising implanting in a patient a device including first and second components having different relative rates of in vivo degradation, the first component having a higher rate of in vivo degradation than the second component, and the first and second components being arranged relative to each other so that, after implantation of the device, the first component degrades in vivo leaving a scaffold formed of the second component, the scaffold having pores into which tissue can infiltrate.
- 38. A method of making a device for tissue repair or replacement, comprising forming a porous scaffold of a first component, and infiltrating the porous scaffold with a second component.
- 45. A method of making a device for tissue repair or replacement, comprising providing a blend of two immiscible polymers having different rates of in vivo degradation, and performing a phase separation of the polymers to produce a two-phase solid structure.
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48. A device for tissue repair or replacement, comprising first and second components having different relative rates of in vivo degradation, the first component having a higher rate of in vivo degradation than the second component, and the first and second components being arranged relative to each other so that, after implantation of the device, the first component degrades in vivo.
Specification