Polymeric systems for drug delivery and uses thereof
First Claim
Patent Images
1. A polymeric drug delivery system, comprising:
- (a) a biodegradable water insoluble polymer that is a solid or wax at 37°
C.;
(b) a biodegradable water soluble polymer that is a liquid at 25°
C.; and
(c) a hydrophobic drug, wherein said polymeric drug delivery system is a liquid or paste at 25°
C.
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Abstract
Biodegradable polymeric implants can provide a safe and efficient means to deliver drugs in the treatment of various diseases. Although a polymeric drug delivery system can be implanted as a solid device within a subject, it is also possible to administer such a system as an injectable liquid which solidifies in vivo. An improved formulation of a polymeric drug delivery system comprises a water insoluble copolymer that is a solid or wax at 37° C., a water soluble polymer that is a liquid at 25° C., and a hydrophobic drug. These drug delivery systems can be administered by injection, and do not require the use of a toxic curing agent or inconvenient temperature manipulations.
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Citations
62 Claims
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1. A polymeric drug delivery system, comprising:
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(a) a biodegradable water insoluble polymer that is a solid or wax at 37°
C.;
(b) a biodegradable water soluble polymer that is a liquid at 25°
C.; and
(c) a hydrophobic drug, wherein said polymeric drug delivery system is a liquid or paste at 25°
C. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method for delivering a drug to a subject, comprising the administration of a polymeric drug delivery system that comprises (a) a biodegradable water insoluble polymer that is a solid or wax at 37°
- C., (b) a biodegradable water soluble polymer that is a liquid at 25°
C., and (c) a hydrophobic drug, wherein said polymeric drug delivery system is a liquid or paste at 25°
C. - View Dependent Claims (25, 26, 27, 28, 29, 30)
- C., (b) a biodegradable water soluble polymer that is a liquid at 25°
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31. A method of preparing a polymeric drug delivery system, comprising the blending of:
- (a) a biodegradable water insoluble polymer that is a solid or wax at 37°
C., (b) a biodegradable water soluble polymer that is a liquid at 25°
C., and (c) a hydrophobic drug, wherein said polymeric drug delivery system is a liquid or paste at 25°
C. - View Dependent Claims (32)
- (a) a biodegradable water insoluble polymer that is a solid or wax at 37°
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33. A triblock copolymer of the formula ABA, wherein A is a block of residues comprising residues which remain after polymerization of one or more monomers selected from the group consisting of hydroxyacetic acid, 2-hydroxypropionic acid and 6-hydroxyhexanoic acid, B is a block of residues comprising residues which remain after the polymerization of one or more monomers selected from the group consisting of alkylene oxide and alkylene glycol, and the copolymer has a consistency, at a temperature within the range of 25-40°
- C., selected from the group consisting of a paste and a liquid, or has a non-solid consistency at 25°
C. - View Dependent Claims (34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47)
- C., selected from the group consisting of a paste and a liquid, or has a non-solid consistency at 25°
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48. A drug delivery system comprising a drug in combination with a triblock copolymer of the formula ABA, wherein A is a block of residues comprising residues which remain after polymerization of one or more monomers selected from the group consisting of hydroxyacetic acid, 2-hydroxypropionic acid and 6-hydroxyhexanoic acid, B is a block of residues comprising residues which remain after the polymerization of one or more monomers selected from the group consisting of alkylene oxide and alkylene glycol, and the copolymer has a consistency, at a temperature within the range of 25-40°
- C., selected from the group consisting of a paste and a liquid, or has a non-solid consistency at 25°
C. - View Dependent Claims (49, 50, 51)
- C., selected from the group consisting of a paste and a liquid, or has a non-solid consistency at 25°
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52. A method of administering a drug to a subject comprising contacting the subject with a drug delivery system comprising a drug in combination with a triblock copolymer of the formula ABA, wherein A is a block of residues comprising residues which remain after polymerization of one or more monomers selected from the group consisting of hydroxyacetic acid, 2-hydroxypropionic acid and 6-hydroxyhexanoic acid, B is a block of residues comprising residues which remain after the polymerization of one or more monomers selected from the group consisting of alkylene oxide and alkylene glycol, and the copolymer has a consistency, at a temperature within the range of 25-40°
- C., selected from the group consisting of a paste and a liquid, or has a non-solid consistency at 25°
C. - View Dependent Claims (53, 54, 55, 56, 57, 58, 59, 60, 61, 62)
- C., selected from the group consisting of a paste and a liquid, or has a non-solid consistency at 25°
Specification