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Phosphorous-linked oligomeric compounds and their use in gene modulation

  • US 20050042647A1
  • Filed: 06/03/2004
  • Published: 02/24/2005
  • Est. Priority Date: 06/06/1996
  • Status: Abandoned Application
First Claim
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1. A composition comprising a first oligomer and a second oligomer, wherein:

  • at least a portion of said first oligomer is capable of hybridizing with at least a portion of said second oligomer, at least a portion of said first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of said first or said second oligomers includes at least one nucleotide having a modification comprising;

    a phosphorothioate;

    phosphorodithioate;

    phosphonate;

    phosphonothioate;

    phosphotriester;

    phosphorothiotriester;

    phosphoramidate;

    phosphorothioamidate;

    phosphinate;

    boronate;

    α

    -D-arabinoftiranosyl;

    or 2′

    -5′

    internucleoside linkage;

    or at least one of said first or said second oligomers contains at least one region of chirally pure internucleoside linkages or includes at least one region of inverted polarity.

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