Systems and methods for detection of analytes in biological fluids
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Accused Products
Abstract
The invention provides a heterogeneous immunoassay for detection of antibodies and antigens based on specific antigen-antibody immune complex formation with multiple antigen-bearing conjugate components. The invention further provides means for optimizing the assay format for the detection of both low and high-affinity antibodies, and provides means for quantitative detection of both antibody and the corresponding antigen present in a sample.
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Citations
49 Claims
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1-31. -31. (canceled)
- 32. A kit comprising a first component comprising a ligand linked, through a chemical spacer, to a solid phase adsorbing composition, a second component comprising a ligand-binding moiety conjugated to an antigen or hapten that binds an antibody to be detected in a sample and a third component comprising the antigen or hapten conjugated to a label.
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33. (Canceled)
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36-40. -40. (Canceled)
Specification