Entrapped binding protein as biosensors
First Claim
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1. A glucose biosensor for in vivo or in vitro use comprising:
- a) at least one mutated binding protein and at least one reporter group attached thereto such that said reporter group provides detectable and reversible signal when said mutated binding protein is exposed to varying glucose concentrations; and
b) an analyte permeable matrix entrapping or encapsulating said at least one mutated binding protein.
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Abstract
The invention is directed to entrapped mutated binding proteins, mutated binding proteins containing reporter groups, compositions of mutated binding proteins containing reporter groups in analyte permeable matrixes, and their use as analyte biosensors both in vitro and in vivo
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Citations
23 Claims
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1. A glucose biosensor for in vivo or in vitro use comprising:
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a) at least one mutated binding protein and at least one reporter group attached thereto such that said reporter group provides detectable and reversible signal when said mutated binding protein is exposed to varying glucose concentrations; and
b) an analyte permeable matrix entrapping or encapsulating said at least one mutated binding protein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22)
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23-50. -50. (canceled)
Specification