Diastolic coronary perfusion detection for timed delivery of therapeutic and/or diagnostic agents
First Claim
1. A method comprising:
- receiving a signal that reflects activity of a heart;
processing the signal to detect closure of an aortic valve of the heart; and
initiating delivery of a therapeutic and/or diagnostic agent to the heart upon detection of closure of the aortic valve.
1 Assignment
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Accused Products
Abstract
During diastolic coronary perfusion, blood perfuses through the heart via the coronary arteries. Delivery of a therapeutic and/or diagnostic agent to the heart during diastolic coronary perfusion allows the therapeutic and/or diagnostic agent to efficiently perfuse through the heart. A medical device according to the invention detects closure of the aortic valve of a heart, and initiates delivery of a therapeutic and/or diagnostic agent upon detection of aortic valve closure. The medical device detects aortic valve closure by processing a signal. Exemplary signals used by the medical device to detect aortic valve closure include left or right ventricular accelerometer signals, left or right ventricular flow signals, left or right ventricular pressure signals, aortic pressure signals, pulse pressure signals, systemic arterial pressure signals, electrogram signals, and phonocardiogram signals
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Citations
38 Claims
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1. A method comprising:
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receiving a signal that reflects activity of a heart;
processing the signal to detect closure of an aortic valve of the heart; and
initiating delivery of a therapeutic and/or diagnostic agent to the heart upon detection of closure of the aortic valve. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8)
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9. A medical device comprising:
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a pump to deliver a therapeutic and/or diagnostic agent to a heart via a catheter; and
a processor means for receiving a signal that reflects activity of the heart, for processing the signal to detect closure of an aortic valve of the heart, and for controlling the pump to deliver the therapeutic and/or diagnostic agent to the heart upon detection of closure of the aortic valve. - View Dependent Claims (10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A system comprising:
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a catheter;
a pump to deliver a therapeutic and/or diagnostic agent to a heart via the catheter;
a sensor to generate a signal that reflects activity of the heart; and
a processor to receive the signal, process the signal to detect closure of an aortic valve of the heart, and control the pump to deliver the therapeutic and/or diagnostic agent to the heart upon detection of closure of the aortic valve. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27)
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28. A computer-readable medium comprising instructions that cause a programmable processor to:
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receive a signal that reflects activity of a heart;
process the signal to detect closure of an aortic valve of the heart; and
control a pump to deliver a therapeutic and/or diagnostic agent to the heart upon detection of closure of the aortic valve. - View Dependent Claims (29, 30, 31)
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32. A system comprising:
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means for detecting activity within a heart and generating a signal as a function of the activity;
means for delivering a therapeutic and/or diagnostic agent to the heart; and
means for processing the signal to detect closure of an aortic valve of the heart, and controlling the delivery means to deliver the therapeutic and/or diagnostic agent upon detection of closure of the aortic valve. - View Dependent Claims (33, 34, 35, 36, 37, 38)
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Specification