Non-invasive method and apparatus for cardiac pacemaker pacing parameter optimization and monitoring of cardiac dysfunction

• US 20050043767A1
• Filed: 09/15/2004
• Published: 02/24/2005
• Est. Priority Date: 11/16/2001
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Belalcazar, Hugo Andres
• Granted Patent: US 7,366,569 B2
• Time in Patent Office: Days
• US Class Current: 607/30
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

A plethysmogram signal is sensed from a patient and provided to a programmer device for monitoring the condition of the patient and for optimizing pacing parameters of a cardiac device implanted in the patient. The programmer device analyzes the plethysmogram signal for cardiac performance associated with different pacing parameters. The cardiac performance is indicated by, for example, a pulse amplitude response, a degree of pulsus alternans, or irregularity in the pressure pulses detected in an atrial fibrillation patient. The pacing parameters resulting in the best cardiac performance are selected as the optimum pacing parameters. In one embodiment, the programmer device monitors a Valsalva maneuver performed by a patient. Optimum pacing parameters are derived by analysis of the plethysmogram signals obtained during performance of the Valsalva maneuver while the patient is paced using different pacing parameters.

Claims

1. An external programmer for an implantable cardiac pacing device, the external programmer comprising:

a transmitter to transmit programming instructions to the implantable cardiac pacing device to program pacing parameters of the implantable cardiac pacing device;

a finger plethysmogram signal detector to provide a finger plethysmogram signal; and

a programmer processor coupled to the transmitter and the finger detector, the programmer programmed to generate the programming instructions, to control the transmitter for transmitting the programming instructions, to process the finger plethysmogram signal to detect pulsus alternans in the finger plethysmogram signal, and to derive a quantitative value related to a degree of the detected pulsus alternans.

2. The external programmer device of claim 1, wherein the finger plethysmogram signal detector comprises a finger clip signal detector.

3. The external programmer device of claim 1, wherein the finger plethysmogram signal detector comprises a photoplethysmogram signal detector.

4. The external programmer device of claim 3, wherein the finger plethysmogram signal detector comprises a pulse oximeter sensor.

5. An external programmer for an implantable cardiac pacing device, the external programmer comprising:

a transmitter to transmit programming instructions to the implantable cardiac pacing device to program pacing parameters of the implantable cardiac pacing device;

a finger plethysmogram signal detector to provide a finger plethysmogram signal; and

a programmer processor coupled to the transmitter and the finger detector, the programmer programmed to generate first programming instructions to control the implantable cardiac pacing device to pace for a plurality of series of paced beats using different selected pacing parameter values for different series of paced beats, to control the transmitter for transmitting the first programming instructions, and to analyze a selected characteristic of the finger plethysmogram signal for each series of paced beats of the plurality of paced beats,

wherein the selected characteristic of the finger plethysmogram signal is selected from at least one of a pulse amplitude detected from the finger plethysmogram signal and a degree of pulsus alternans detected from the finger plethysmogram signal.

6. The external programmer of claim 5, wherein the programmer processor is programmed to determine an approximately optimal pacing parameter value based on the analysis of the selected characteristic of the finger plethysmogram signal for the each series of paced beats of the plurality of paced beats.

7. The external programmer of claim 6, wherein the selected pacing parameter values includes values of at least an AV delay.

8. The external programmer of claim 6, wherein the selected pacing parameter values includes values of at least a pacing site parameter.

9. The external programmer of claim 6, wherein the selected pacing parameter values includes values of at least a pacing mode parameter.

10. The external programmer of claim 6, wherein the programmer processor is programmed to generate programming instructions to be transmitted to the implantable cardiac pacing device to control the implantable cardiac pacing device to pace for a plurality of series of paced beats separated by non-pacing beats.

11. The external programmer of claim 10, wherein the programmer processor is programmed to analyze characteristics of the finger plethysmogram signal during the paced beats in each series of the plurality of paced beats and during non-paced beats before and after each series of paced beats.

12. A non-invasive method for optimizing pacing parameters of a cardiac device implanted in a patient, the method comprising:

detecting a finger plethysmogram signal from the patient during pacing with a selected pacing parameter value;

monitoring a Valsalva maneuver performed by the patient while detecting the finger plethysmogram signal;

analyzing the finger plethysmogram signal to obtain a cardiac performance parameter indicative of cardiac performance;

adjusting the selected pacing parameter value; and

obtaining an improvement in the cardiac performance parameter by repeating the detecting the finger plethysmogram signal, the monitoring the Valsalva maneuver, the analyzing the finger plethysmogram signal, and the adjusting the selected pacing parameter value.

13. The method of claim 12, wherein repeating the detecting the finger plethysmogram signal, the monitoring the Valsalva maneuver, the analyzing the finger plethysmogram signal, and the adjusting the selected pacing parameter value comprises repeating the detecting the finger plethysmogram signal, the monitoring the Valsalva maneuver, the analyzing the finger plethysmogram signal, and the adjusting the selected pacing parameter value for a plurality of pacing series intervals separated by periods of non-paced rhythm, wherein adjusting the selected pacing parameter value includes adjusting the selected pacing parameter value to a different value for each different pacing series interval of the plurality of pacing series intervals.

14. The method of claim 13, further comprising attaching a photoplethysmogram signal detector to the finger of the patient.

15. The method of claim 13, further comprising attaching a pulse oximeter sensor to the finger of the patient.

16. The method of claim 12, wherein analyzing the finger plethysmogram signal to obtain the cardiac performance parameter indicative of cardiac performance comprises analyzing the finger plethysmogram signal during performance of the Valsalva maneuver by the patient to obtain a cardiac performance parameter related to a filling pressure.

17. The method of claim 16, wherein the filling pressure comprises pulmonary-capillary wedge pressure.

18. The method of claim 16, wherein the filling pressure comprises left ventricular diastolic pressure.

19. A non-invasive method for optimizing pacing parameters of a cardiac device implanted in a patient, the method comprising:

detecting a finger plethysmogram signal from the patient during pacing with a selected pacing parameter value;

analyzing the finger plethysmogram signal to monitor a degree of pulsus alternans;

adjusting the selected pacing parameter value; and

reducing the degree of pulsus alternans by repeating the detecting the finger plethysmogram signal, the analyzing the finger plethysmogram signal, and the adjusting the selected pacing parameter value.

20. The method of claim 19, wherein analyzing the finger plethysmogram signal to monitor the degree of pulsus alternans comprises determining an amplitude ratio of pulses detected in the finger plethysmogram signal.

21. The method of claim 19, wherein reducing the degree of pulsus alternans comprises minimizing the degree of pulsus alternans.

22. The method of claim 21, wherein adjusting the selected pacing parameter value includes adjusting a value of one of an AV delay, a pacing site parameter, and a pacing mode parameter.

23. A non-invasive method for optimizing pacing parameters of a cardiac device implanted in a patient, the method comprising:

detecting a finger plethysmogram signal from the patient during pacing with a selected pacing parameter value;

analyzing the finger plethysmogram signal to monitor a finger plethysmogram pulse amplitude in response to the pacing;

adjusting the selected pacing parameter value; and

increasing the finger plethysmogram pulse amplitude in response to the pacing by repeating the detecting the finger plethysmogram signal, the analyzing the finger plethysmogram signal, and the adjusting the selected pacing parameter value.

24. The method of claim 23, wherein increasing the finger plethysmogram pulse amplitude in response to the pacing comprises maximizing the finger plethysmogram pulse amplitude in response to pacing.

25. The method of claim 24, wherein adjusting the selected pacing parameter value includes adjusting a value of one of an AV delay, a pacing site parameter, and a pacing mode parameter.

26. A non-invasive method for optimizing pacing parameters of a cardiac device implanted in a patient, the method comprising:

detecting a finger plethysmogram signal from the patient during pacing with a selected pacing parameter value;

analyzing the finger plethysmogram signal to monitor pulse pressure;

adjusting the selected pacing parameter value; and

regularizing the pulse pressure by repeating the detecting the finger plethysmogram signal, the analyzing the finger plethysmogram signal, and the adjusting the selected pacing parameter value.

27. The method of claim 26, wherein analyzing the finger plethysmogram signal to monitor pulse pressure comprises analyzing the finger plethysmogram signal to detect peak amplitudes of pulses in the finger plethysmogram signal, and regularizing the pulse pressure comprises making the peak amplitudes of pulses in the finger plethysmogram signal more uniform.

28. The method of claim 27, wherein adjusting the selected pacing parameter value includes adjusting a value of one of an AV delay, a pacing site parameter, and a pacing mode parameter.

29. A non-invasive method for optimizing pacing parameters of a cardiac device, the method comprising:

delivering a pacing sequence including a plurality of series of paced beats, each of the series of paced beats preceded and followed by a series of non-paced beats and associated with one value of at least one pacing parameter, with a different value of the at least one pacing parameter used for each of the series of paced beats;

detecting a finger plethysmogram signal during the delivery of the pacing sequence;

analyzing the finger plethysmogram signal to monitor a parameter indicative of cardiac performance; and

optimizing the at least one pacing parameter based on the analysis of the finger plethysmogram signal.

30. The method of claim 29, wherein analyzing the finger plethysmogram signal comprises analyzing the finger plethysmogram signal to monitor the parameter indicative of cardiac performance for each series of the plurality of series of paced beats, and wherein optimizing the at least one pacing parameter comprises determining the value of the at least one pacing parameter associated with the best cardiac performance as indicated by the finger plethysmogram signal.

31. The method of claim 30, wherein the parameter indicative of cardiac performance comprises a degree of pulsus alternans, and wherein optimizing the at least one pacing parameter comprises determining the value of the at least one pacing parameter associated with a minimum degree of pulsus alternans.

32. The method of claim 30, wherein the parameter indicative of cardiac performance comprises a pulse amplitude of the finger plethysmogram, and wherein optimizing the at least one pacing parameter comprises determining the value of the at least one pacing parameter associated with a maximum pulse amplitude of the finger plethysmogram.

33. The method of claim 30, wherein the parameter indicative of cardiac performance comprises peak amplitudes of the finger plethysmogram, and wherein optimizing the at least one pacing parameter comprises determining the value of the at least one pacing parameter associated with most uniform peak amplitudes of the finger plethysmogram.

34. The method of claim 30, wherein optimizing the at least one pacing parameter comprises optimizing an AV delay.

35. The method of claim 30, wherein optimizing the at least one pacing parameter comprises optimizing pacing sites.