Biomaterial comprising microfeatures

• US 20050043820A1
• Filed: 10/14/2002
• Published: 02/24/2005
• Est. Priority Date: 10/12/2001
• Status: Abandoned Application

• Current Assignee: James O. Browning
• Original Assignee: James O. Browning
• Inventors: Browning, James
• Application Number:
  US10/492,473
• Publication Number:
  US 20050043820A1
• Time in Patent Office: Days
• US Class Current: 623/23.740
• CPC Class Codes: A61F 2/0045 Support slings
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 27/50 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 27/56 Porous materials, e.g. foams or sponges
• CPC Class Codes: A61L 31/14 Materials characterised by their function or physical properties , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
• CPC Class Codes: A61L 31/146 Porous materials, e.g. foams or sponges

Abstract

The present invention relates to biomaterials for use in surgical implants. The biomaterial can include micropatterns; such as microgrooves and microfeatures such as pores, pits or slits on the surface of the biomaterial. The micropattern can be parallel microgrooves capable of influencing the orientation and alignment of cells proliferating on the surface of the biomaterial. The microfeatures enable tissue ingrowth into the biomaterial and may extend through all or part of the biomaterial, allowing the rapid integration of the implant into the tissue.

Claims

1. A biomaterial comprising at least one micropattern on at least one surface of the biomaterial the micropattern including a plurality of substantially parallel grooves said grooves being capable of influencing the orientation and alignment of cells proliferating on the surface of the biomaterial.

2. A biomaterial as claimed in claim 1 wherein the grooves are 0.5 to 20 μ

m in width and 0.25 to 20 μ

m in depth.

3. A biomaterial as claimed in claim 1 wherein the grooves are 5 μ

m in width and 5 μ

m in depth.

4. A biomaterial as claimed in claim 1 wherein the grooves are separated by ridges of between 1.0 to 20 μ

m in width.

5. A biomaterial as claimed in claim 4 the grooves are separated by ridges of 5 μ

m in width.

6. A biomaterial as claimed in claim 1 wherein the grooves present on the surface of the biomaterial are aligned in the same direction.

7. A biomaterial as claimed in claim 1 wherein the grooves are arranged in groups with the grooves in a particular group being aligned in a similar direction, and different groups of grooves being aligned in different directions.

8. A biomaterial as claimed in claim 4 wherein the ridges are formed by square pillars and the base of the microgroove is substantially perpendicular to the side walls of the square pillars.

9. A biomaterial as claimed in claim 4 wherein the ridges are formed by square pillars and the base of the microgrooves is bevelled in relation to the side walls of the square pillars.

10. A biomaterial as claimed in claim 8 wherein the side walls of the pillars are arcuate.

11. A biomaterial as claimed in claim 1 wherein the grooves extend along the length of at least one surface of the biomaterial.

12. A biomaterial as claimed in claim 1 wherein the grooves extend along a first surface and a second opposite surface of the biomaterial.

13. A biomaterial as claimed in claim 1 wherein the grooves are only present in a defined area of the biomaterial.

14. A biomaterial as claimed in claim 1 wherein the biomaterial is between 50 μ

m and 300 μ

m thick.

15. A biomaterial as claimed in claim 1 wherein the biomaterial is 200 μ

m thick.

25. A biomaterial as claimed in claim 13 wherein micro-features are distributed only in a particular portion of the surface of the biomaterial.

31. A biomaterial as claimed in claim 1 wherein the biomaterial is not absorbed into the surrounding tissues over time.

32. A biomaterial as claimed in claim 1 wherein the biomaterial is absorbable into the surrounding tissues over time.

33. A biomaterial as claimed in claim 32 wherein the biomaterial is absorbable into the surrounding tissues in less than 12 to 18 months following insertion of the biomaterial into the body.

34. A biomaterial as claimed in claim 32 wherein the biomaterial is absorbable into the surrounding tissue in less than 10 to 12 months following the insertion of the biomaterial into the body.

35. A biomaterial as claimed in claim 1 which further comprises at least one microfeature to promote tissue ingrowth wherein the microfeature is at least one pore which extends through the biomaterial from a first surface of the biomaterial to a second opposite surface of the biomaterial said pore ranging in width across the surface of the biomaterial from 50 μ

m to 300 μ

m.

36. A biomaterial as claimed in claim 1 which further comprises at least one microfeature to promote tissue ingrowth wherein the microfeature comprises at least one pit which indents but does not extend through the biomaterial said pit ranging in width across the surface of the biomaterial from 50 μ

m to 300 μ

m.

37. A biomaterial as claimed in claim 1 which further comprises at least one microfeature to promote tissue ingrowth wherein the microfeature comprises at least one slit which extends through the biomaterial from a first surface of the biomaterial to a second opposite surface in the biomaterial wherein said slit from 50 μ

m to 2 mm in length and from 50 μ

m to 500 μ

m in width.

16. A biomaterial comprising at least one microfeature to promote tissue ingrowth wherein the microfeature is at least one pore which extends through the biomaterial from a first surface of the biomaterial to a second opposite surface of the biomaterial said pore ranging in width across the surface of the biomaterial from 50 μ

m to 300 μ

m.

24. A biomaterial as claimed in claim 16 wherein microfeatures are distributed across the complete surface of the biomaterial.

26. A biomaterial as claimed in claim 16 wherein microfeatures are created by post synthesis modification of synthetic biomaterial.

27. A biomaterial as claimed in claim 26 wherein microfeatures are created by post synthesis treatment of the surface of synthetic biomaterial by a laser.

28. A biomaterial as claimed in claim 16 wherein microfeatures are created during synthesis of the synthetic biomaterial.

29. A biomaterial as claimed in claim 28 wherein the microfeatures formed during the synthesis of synthetic biomaterial are formed by spaces between the waft and weave of mono-filament or multi-filament yarns when they are woven to form a mesh.

30. A biomaterial as claimed in claim 28 wherein the microfeatures formed during the synthesis of synthetic biomaterial are formed by the inter-filament spaces created when mono-filaments are twisted to create multi-filaments, the multi-filaments then being woven to form a mesh.

17. A biomaterial comprising at least one microfeature to promote tissue ingrowth wherein the microfeature comprises at least one pit which indents but does not extend through the biomaterial said pit ranging in width across the surface of the biomaterial from 50 μ

m to 300 μ

m.

23. A biomaterial as claimed in claim 17 to wherein the microfeature ranges in width across the biomaterial from 100-150 μ

m.

18. A biomaterial comprising at least one microfeature to promote tissue ingrowth wherein the microfeature comprises at least one slit which extends through the biomaterial from a first surface of the biomaterial to a second opposite surface in the biomaterial wherein said slit from 50 μ

m to 2 mm in length and from 50 μ

m to 500 μ

m in width.

19. A biomaterial as claimed in claim 18 wherein the slit is of length from 50 μ

m to 1 mm and width 100 μ

m.

20. A biomaterial as claimed in claim 18 wherein the slit is of length 200 μ

m and width 50 μ

m.

21. A biomaterial as claimed claim 18 wherein the slit is orientated such that the longest dimension is parallel to the longitudinal axis of the biomaterial.

22. A biomaterial as claimed in claim 18 wherein the slit is orientated such that the longest dimension is not parallel to the longitudinal axis of the implant.

38-40. -40. (Cancelled)