Biosynthetic oncolytic molecules and uses therefor
First Claim
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1. A biosynthetic oncolytic molecule comprising an apoptotic component derived from osteopontin and at least one biomodular component, forming a molecule which promotes apoptosis, comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 8, 10, 12, 15, 16, 17, 18, and conservative substitutions therein.
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Accused Products
Abstract
Biosynthetic oncolytic molecules including an apoptotic domain derived from osteopontin have been developed which are capable of promoting cellular apoptosis.
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Citations
19 Claims
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1. A biosynthetic oncolytic molecule comprising an apoptotic component derived from osteopontin and at least one biomodular component, forming a molecule which promotes apoptosis, comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 8, 10, 12, 15, 16, 17, 18, and conservative substitutions therein.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 14, 17, 18)
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12. An isolated nucleic acid molecule encoding a biosynthetic oncolytic molecule comprising an apoptotic component derived from osteopontin and at least one biomodular component, forming a molecule which promotes apoptosis, comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 8, 10, 12, 15, 16, 17, 18, and conservative substitutions therein.
- View Dependent Claims (13)
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15. An expression vector comprising the nucleic acid molecule selected from the group consisting of SEQ ID NO:
- 7, SEQ ID NO;
9, SEQ ID NO;
11, SEQ ID NO;
13, and SEQ ID NO;
17. - View Dependent Claims (16)
- 7, SEQ ID NO;
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19. A method of modulating an apoptotic response in a cell comprising contacting the cell with a biosynthetic oncolytic molecule comprising an apoptotic component derived from osteopontin and at least one biomodular component, forming a molecule which promotes apoptosis, comprising an amino acid sequence selected from the group consisting of SEQ ID NOS:
- 8, 10, 12, 15, 16, 17, 18, and conservative substitutions therein in an amount and for a period of time to induce an apoptotic response.
Specification