Method and system for determining insulin dosing schedules and carbohydrate-to-insulin ratios in diabetic patients
First Claim
1. A method of adjusting an insulin dosing schedule involving the combination of a base insulin dosage administered over a given time interval (Basal Insulin) coupled with an additional insulin dosage administered in relation to a meal taken during the given time interval (Meal Insulin) comprising estimating a desired change in the Meal Insulin and then determining a change in the Basal Insulin from the difference between the change in total insulin prescribed for the given time interval (Prescription Insulin) less the estimated desired change in the Meal Insulin for the given, time interval.
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Abstract
Method for digitally determining the daily insulin regimen for a diabetic patient. The invention divides the patient'"'"'s day into adjustable time intervals containing basal insulin dosage rates and Carbohydrate-to-Insulin Ratio(s) (for determining meal insulin doses). The invention identifies the Corrective Insulin doses over a time interval as an “error” in the Prescription Insulin (Basal Insulin+Meal Insulin). Methods involve first estimating the change to one of these two components of Prescription Insulin, and then determining the change to the other by subtracting from the error. One method estimates Change in Meal Insulin distributed among intervals proportional to old Meal Insulin. Another method lumps After-Meal Corrective Insulin together with Meal Insulin. Another method splits the interval at the After-Meal Corrective Dose and determines Basal from Time-Boundary Corrective Dose. Data may be obtained from the previous day, and a small fraction of error applied, leading to asymptotic reduction of error. Data may be obtained from recent history, and a larger fraction of error applied by doctor or automatic method.
501 Citations
131 Claims
- 1. A method of adjusting an insulin dosing schedule involving the combination of a base insulin dosage administered over a given time interval (Basal Insulin) coupled with an additional insulin dosage administered in relation to a meal taken during the given time interval (Meal Insulin) comprising estimating a desired change in the Meal Insulin and then determining a change in the Basal Insulin from the difference between the change in total insulin prescribed for the given time interval (Prescription Insulin) less the estimated desired change in the Meal Insulin for the given, time interval.
- 8. A method of adjusting an insulin dosing schedule involving the combination of a base insulin administered over a given time interval (Basal Insulin) coupled with an additional insulin dosage administered in relation to a meal taken during the given time interval (Meal Insulin) comprising estimating a desired change in the Basal Insulin and then determining a change in the Meal Insulin from the difference between the change in total insulin prescribed for the given time interval (Prescription Insulin) and the estimated desired change in the Basal Insulin for the given time interval.
- 16. A method of adjusting an insulin dosing schedule involving the combination of a base insulin dosage administered over a given time interval (Basal Insulin) coupled with an additional insulin dosage administered in relation to a meal taken during the given time interval (Meal Insulin) comprising a time interval that starts near the end of a meal, and in which an after meal insulin dosage is administered intermediate between the start and the end of the given time interval, and in which a change to the Basal Insulin for the time interval is determined based on a later portion of the time interval, the change in the Basal Insulin being used to determine a change in the Basal Insulin for an earlier portion of the time interval which is subtracted from a desired change in the prescribed insulin dosage (Prescription Insulin) to obtain a change in the Meal Insulin for the given time interval.
- 27. The method of converting a change in an insulin dosage administered in relation to a meal taken during a given time interval (Meal Insulin) to a change in carbohydrate-to-insulin ratio by multiplying the Meal Insulin by the calculus derivative of carbohydrate-to-insulin ratio with respect to Meal Insulin for a given time interval.
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Specification