Indirect delivery of growth factors into the central nervous system
First Claim
1. A method of delivering a treatment to the central nervous system, including the steps of:
- administering a therapeutic intramuscularly into muscles innervated by nerves chosen from the group consisting of cranial nerves and spinal nerves; and
transporting the therapeutic peripherally through nerves into the CNS and to the site of treatment.
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Abstract
The present invention provides a method of delivering a treatment to the central nervous system, including the steps of administering a therapeutic intramuscularly into muscles innervated by nerves chosen from the group consisting of cranial nerves and spinal nerves, and transporting the therapeutic peripherally through nerves into the CNS and to the site of treatment. The present invention provides a method of treating a neural disorder or a part of the body by administering an effective amount of a compound affecting neural cells into muscles innervated by cranial and/or spinal nerves, and affecting neural cells. The present invention also provides a method of treating a spinal cord injury by administering an effective amount of a compound affecting neural cells into musculature directly innervated by the spinal cord, and affecting neural cells. The present invention further provides a method of treating Parkinson'"'"'s disease by administering an effective amount of a compound affecting neural cells into musculature innervated by the motor trigeminal nerve, and affecting neural cells involved in Parkinson'"'"'s disease. Finally, the present invention also provides a method of treating amyotrophic lateral sclerosis by administering an effective amount of a compound affecting neural cells into musculature innervated by cranial and/or spinal nerves, and affecting neural cells involved in amyotrophic lateral sclerosis.
14 Citations
77 Claims
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1. A method of delivering a treatment to the central nervous system, including the steps of:
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administering a therapeutic intramuscularly into muscles innervated by nerves chosen from the group consisting of cranial nerves and spinal nerves; and
transporting the therapeutic peripherally through nerves into the CNS and to the site of treatment. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
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24. A method of treating a neural disorder, including the steps of:
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administering intramuscularly an effective amount of a therapeutic into muscles innervated by nerves chosen from the group consisting of cranial nerves and spinal nerves;
transporting the therapeutic peripherally through nerves into the CNS; and
affecting neural cells. - View Dependent Claims (25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46)
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47. A method of treating a part of the body, including the steps of:
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administering intramuscularly an effective amount of a therapeutic into muscles innervated by nerves chosen from the group consisting of cranial nerves and spinal nerves;
transporting the therapeutic peripherally through nerves into the CNS; and
affecting neural cells. - View Dependent Claims (48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69)
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70. A method of treating a spinal cord injury, including the steps of
administering an effective amount of a therapeutic into musculature directly innervated by the spinal cord; -
transporting the therapeutic peripherally through nerves into the CNS and past the blood-brain barrier; and
affecting neural cells. - View Dependent Claims (71)
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72. A method of treating Parkinson'"'"'s disease, including the steps of
administering an effective amount of a therapeutic into musculature innervated by the motor trigeminal nerve, said therapeutic affecting neural cells; -
transporting the therapeutic peripherally through nerves into the CNS and past the blood-brain barrier; and
affecting neural cells involved in Parkinson'"'"'s disease. - View Dependent Claims (73, 74, 75, 76)
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77. A method of treating amyotrophic lateral sclerosis, including the steps of
administering an effective amount of a therapeutic into musculature innervated by nerves chosen from the group consisting of cranial and spinal nerves, said therapeutic affecting neural cells; -
transporting the therapeutic peripherally through nerves into the CNS and past the blood-brain barrier; and
affecting neural cells involved in amyotrophic lateral sclerosis.
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Specification
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Current AssigneeJohn Gianutsos, Michael Hutchinson
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Original AssigneeJohn Gianutsos, Michael Hutchinson
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InventorsGianutsos, John, Hutchinson, Michael
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Application NumberUS10/927,301Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current514/1.200CPC Class CodesA61K 38/185 Nerve growth factor [NGF]; ...A61K 9/0085 Brain, e.g. brain implants;...
