Implantable biosensor devices for monitoring cardiac marker molecules
First Claim
1. An implantable sensor system for determining the presence or amount of an analyte in a patient, comprising:
- a. a sensor element comprising a biological recognition element associated with a portion or portions of a transducer, the biological recognition element being capable of specifically binding to a substance in the patient in an amount related to the presence or amount of the analyte and wherein when the substance is bound a detectable signal is produced;
b. a controller associated with the sensor element to measure the detectable signal and relate the amount of the detectable signal measured with the presence or amount of analyte present in the patient; and
c. a protective member located adjacent the sensor element to shield the biological recognition member from a surrounding environment for a selectable time period.
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Accused Products
Abstract
An implantable biosensor system is disclosed for determining levels of cardiac markers in a patient to aid in the diagnosis, determination of the severity and management of cardiovascular diseases. The sensor includes nanowire sensor elements having a biological recognition element attached to a nanowire transducer that specifically binds to the cardiac marker being measured. Each of the sensor elements is associated with a protective member that prevents the sensor element from interacting with the surrounding environment. At a selected time, the protective member may be disabled, thereby allowing the sensor element to begin sensing signals within a living body.
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Citations
46 Claims
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1. An implantable sensor system for determining the presence or amount of an analyte in a patient, comprising:
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a. a sensor element comprising a biological recognition element associated with a portion or portions of a transducer, the biological recognition element being capable of specifically binding to a substance in the patient in an amount related to the presence or amount of the analyte and wherein when the substance is bound a detectable signal is produced;
b. a controller associated with the sensor element to measure the detectable signal and relate the amount of the detectable signal measured with the presence or amount of analyte present in the patient; and
c. a protective member located adjacent the sensor element to shield the biological recognition member from a surrounding environment for a selectable time period. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method for determining the presence or amount of an analyte present in a patient, comprising:
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a. implanting in the patient a sensor element comprising a biological recognition element associated with a portion or portions of a transducer, the biological recognition element being capable of specifically binding to a substance in the patient in an amount related to the presence or amount of the analyte and wherein when the substance is bound to the biological recognition element a detectable signal is produced; and
a controller connected to the sensor element adapted to measure detectable signal produced and that can relate the amount of detectable signal measured with the presence or amount of analyte present in the patient;
b. contacting the biological recognition element to tissue or fluid in the patient to allow the substance to bind to the biological recognition element;
c. measuring the amount of detectable signal produced when the substance binds to the biological recognition element; and
d. relating the amount of detectable signal produced to the amount or presence of analyte present in the patient. - View Dependent Claims (23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42)
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43. A method of diagnosing, determining the severity of or managing cardiovascular disease in a patient comprising;
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a. implanting into the patient a sensor comprising a plurality of sensor elements each sensor element comprising a biological recognition element associated with a portion or portions of a transducer, the biological recognition element being capable of specifically binding to a substance in the patient in an amount related to the level of a cardiac marker and wherein when the substance is bound a detectable signal is produced, b. activating one or more of the sensor elements by disabling one or more protective members located adjacent the sensor to shield the biological recognition member from a surrounding environment;
c. measuring the amount of detectable signal produced;
d. relating the amount of detectable signal produced to the level of the cardiac marker present in the patient;
e. comparing the measured level of the cardiac marker to preselected levels of such cardiac marker to diagnosis, determine the severity of or manage cardiovascular disease. - View Dependent Claims (44, 45, 46)
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Specification