Barrier device for ostium of left atrial appendage
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Accused Products
Abstract
A membrane applied to the ostium of an atrial appendage for blocking blood from entering the atrial appendage which can form blood clots therein is disclosed. The membrane also prevents blood clots in the atrial appendage from escaping therefrom and entering the blood stream which can result in a blocked blood vessel, leading to strokes and heart attacks. The membranes are percutaneously installed in patients experiencing atrial fibrillations and other heart conditions where thrombosis may form in the atrial appendages. A variety of means for securing the membranes in place are disclosed. The membranes may be held in place over the ostium of the atrial appendage or fill the inside of the atrial appendage. The means for holding the membranes in place over the ostium of the atrial appendages include prongs, stents, anchors with tethers or springs, disks with tethers or springs, umbrellas, spiral springs filling the atrial appendages, and adhesives. After the membrane is in place a filler substance may be added inside the atrial appendage to reduce the volume, help seal the membrane against the ostium or clot the blood in the atrial appendage. The membranes may have anticoagulants to help prevent thrombosis. The membranes be porous such that endothelial cells cover the membrane presenting a living membrane wall to prevent thrombosis. The membranes may have means to center the membranes over the ostium. Sensors may be attached to the membrane to provide information about the patient.
168 Citations
97 Claims
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1-82. -82. (canceled).
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83. A method of preventing thrombus in the atrial appendage of a patient from entering the blood stream, said method comprising:
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providing a membrane between the atrial appendage and the atrium;
securing the membrane over an ostium of the atrial appendage by extending engagement members substantially outwardly from adjacent an edge of the membrane into the atrial appendage through the ostium of the atrial appendage;
piercing the wall of the atrial appendage with the engagement members extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
further securing the membrane over the ostium of the atrial appendage adhesively;
thereby;
blocking blood flow to prevent thrombus from flowing between the atrial appendage.
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84. A method of preventing atrial appendage thrombus from entering the blood stream comprising:
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providing a membrane between the atrial appendage and the atrium;
securing the membrane over an ostium of the atrial appendage by extending engagement members substantially outwardly from adjacent an edge of the membrane into the atrial appendage through the ostium of the atrial appendage;
piercing the wall of the atrial appendage with the engagement members extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
further attaching the membrane to the ostium with an adhesive;
thereby;
blocking blood flow to prevent thrombus from flowing between the atrial appendage.
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85. A method of preventing atrial appendage thrombus from entering the blood stream comprising:
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providing a membrane between the atrial appendage and the atrium;
securing the membrane over an ostium of the atrial appendage by extending engagement members substantially outwardly from adjacent an edge of the membrane into the atrial appendage through the ostium of the atrial appendage;
piercing the wall of the atrial appendage with the engagement members extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
providing a means for centering the membrane over the ostium of the atrial appendage to provide a good seal, by attaching a centering rim to the membrane for insertion into the ostium of the atrial appendage;
thereby;
blocking blood flow to prevent thrombus from flowing between the atrial appendage and the atrium.
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86. A method of preventing thrombus in the atrial appendage of a patient from entering the blood stream, said method comprising:
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providing a filter membrane between the atrial appendage and the atrium;
securing the filter membrane over an ostium of the atrial appendage by extending engagement members substantially outwardly from adjacent an edge of the filter membrane into the atrial appendage through the ostium of the atrial appendage;
piercing the wall of the atrial appendage with the engagement members extending into the atrial appendage wall substantially adjacent the ostium to secure the filter membrane in place; and
further securing the filter membrane over the ostium of the atrial appendage adhesively;
thereby;
filtering blood flow to prevent thrombus from flowing between the atrial appendage and the atrium.
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87. A method of preventing atrial appendage thrombus from entering the blood stream comprising:
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providing a filter membrane between the atrial appendage and the atrium;
securing the filter membrane over an ostium of the atrial appendage by extending engagement members substantially outwardly from adjacent an edge of the filter membrane into the atrial appendage through the ostium of the atrial appendage;
piercing the wall of the atrial appendage with the engagement members extending into the atrial appendage wall substantially adjacent the ostium to secure the filter membrane in place; and
further attaching the filter membrane to the ostium with an adhesive;
thereby;
filtering blood flow to prevent thrombus from flowing between the atrial appendage and the atrium.
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88. A method of preventing atrial appendage thrombus from entering the blood stream comprising:
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providing a filter membrane between the atrial appendage and the atrium;
securing the filter membrane over an ostium of the atrial appendage by extending engagement members substantially outwardly from adjacent an edge of the filter membrane into the atrial appendage through the ostium of the atrial appendage;
piercing the wall of the atrial appendage with the engagement members extending into the atrial appendage wall substantially adjacent the ostium to secure the filter membrane in place; and
providing a means for centering the filter membrane over the ostium of the atrial appendage to provide a good seal, by attaching a centering rim to the filter membrane for insertion into the ostium of the atrial appendage;
thereby;
filtering blood flow to prevent thrombus from flowing between the atrial appendage and the atrium.
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89. A method of preventing atrial appendage thrombus from entering the blood stream comprising:
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securing a membrane over an ostium of the atrial appendage by extending prongs from adjacent an edge of the membrane into the atrial appendage through the ostium;
attaching bulbs on the ends of the prongs during deployment to prevent puncturing the interior of the atrial appendages prematurely and causing emboli; and
piercing the wall of the atrial appendage with the prongs extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place;
thereby;
blocking the atrial appendage ostium with the membrane preventing blood from entering the atrial appendage and forming thrombus therein and preventing thrombus formed therein from leaving.
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90. A method of preventing atrial appendage thrombus from entering the blood stream comprising:
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securing a membrane over an ostium of the atrial appendage by extending prongs from adjacent an edge of the membrane into the atrial appendage through the ostium;
piercing the wall of the atrial appendage with the prongs extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
further securing the membrane over the ostium of the atrial appendage adhesively;
thereby;
blocking the atrial appendage ostium with the membrane preventing blood from entering the atrial appendage and forming thrombus therein and preventing thrombus formed therein from leaving.
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91. A method of preventing atrial appendage thrombus from entering the blood stream comprising:
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securing a membrane over an ostium of the atrial appendage by extending prongs from adjacent an edge of the membrane into the atrial appendage through the ostium;
piercing the wall of the atrial appendage with the prongs extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
vacuuming the atrial appendage for removing thrombus from therein and for collapsing the atrial membrane;
thereby;
blocking the atrial appendage ostium with the membrane preventing blood from entering the atrial appendage and forming thrombus therein and preventing thrombus formed therein from leaving.
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92. A method of preventing atrial appendage thrombus from entering the blood stream comprising:
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securing a membrane over an ostium of the atrial appendage by extending prongs from adjacent an edge of the membrane into the atrial appendage through the ostium;
piercing the wall of the atrial appendage with the prongs extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
blocking the atrial appendage ostium by filling the atrial appendage with a membrane material;
thereby;
blocking the atrial appendage ostium with the membrane preventing blood from entering the atrial appendage and forming thrombus therein and preventing thrombus formed therein from leaving.
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93. A method of preventing atrial appendage thrombus from entering the blood stream comprising:
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securing a membrane over an ostium of the atrial appendage by extending prongs from adjacent an edge of the membrane into the atrial appendage through the ostium;
piercing the wall of the atrial appendage with the prongs extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
injecting a sealant material into the atrial appendage to seal the membrane against the ostium to prevent leakage;
thereby;
blocking the atrial appendage ostium with the membrane preventing blood from entering the atrial appendage and forming thrombus therein and preventing thrombus formed therein from leaving.
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94. A method of preventing atrial appendage thrombus from entering the blood stream comprising:
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securing a membrane over an ostium of the atrial appendage by extending prongs from adjacent an edge of the membrane into the atrial appendage through the ostium;
piercing the wall of the atrial appendage with the prongs extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
injecting a filler material into the atrial appendage to reduce the volume of the atrial appendage;
thereby;
blocking the atrial appendage ostium with the membrane preventing blood from entering the atrial appendage and forming thrombus therein and preventing thrombus formed therein from leaving.
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95. A method for preventing atrial appendage thrombus from entering the blood stream comprising:
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securing a membrane over an ostium of the atrial appendage by extending prongs from adjacent an edge of the membrane into the atrial appendage through the ostium;
piercing the wall of the atrial appendage with the prongs extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
providing a means for centering the membrane over the ostium to provide a good seal, by attaching a centering rim to the membrane for insertion into the ostium of the atrial appendage;
thereby;
blocking the atrial appendage ostium with the membrane preventing blood from entering the atrial appendage and forming thrombus therein and preventing thrombus formed therein from leaving.
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96. A method for preventing atrial appendage thrombus from entering the blood stream comprising:
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securing a membrane over an ostium of the atrial appendage by extending prongs from adjacent an edge of the membrane into the atrial appendage through the ostium;
piercing the wall of the atrial appendage with the prongs extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
attaching markers to the membrane for observing the position of the membrane as it is placed in the ostium of the atrial appendage;
thereby;
blocking the atrial appendage ostium with the membrane preventing blood from entering the atrial appendage and forming thrombus therein and preventing thrombus formed therein from leaving.
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97. A method for preventing atrial appendage thrombus from entering the blood stream comprising:
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securing a membrane over an ostium of the atrial appendage by extending prongs from adjacent an edge of the membrane into the atrial appendage through the ostium;
piercing the wall of the atrial appendage with the prongs extending into the atrial appendage wall substantially adjacent the ostium to secure the membrane in place; and
attaching sensors to the membrane for providing information about the patient;
thereby;
blocking the atrial appendage ostium with the membrane preventing blood from entering the atrial appendage and forming thrombus therein and preventing thrombus formed therein from leaving.
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Specification