Ceramic-coated instruments for medical use, ceramic-coated instruments for studying living organisms and process for producing the same

• US 20050049632A1
• Filed: 01/22/2003
• Published: 03/03/2005
• Est. Priority Date: 01/22/2002
• Status: Abandoned Application

• Current Assignee: JFE Steel Corporation (JFE Holdings Incorporated)
• Original Assignee: JFE Steel Corporation (JFE Holdings Incorporated)
• Inventors: Fukuda, Hiroyuki, Inokuti, Yukio, Ebara, Masaaki, Mori, Hirotaro
• Application Number:
  US10/381,306
• Publication Number:
  US 20050049632A1
• Time in Patent Office: Days
• US Class Current: 606/205
• CPC Class Codes: A61B 10/02 Instruments for taking cell samples or for biopsy A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48
• CPC Class Codes: A61B 10/06 Biopsy forceps , e.g. with cup-shaped jaws
• CPC Class Codes: A61B 17/06 Needles ; Sutures; Needle-suture combinations; Holders or packages for needles or suture materials puncturing needles A61B17/34; hypodermic needles A61M5/32 ; sewing needles D05B85/00
• CPC Class Codes: A61B 17/06066 Needles, e.g. needle tip configurations making needles B21G1/00
• CPC Class Codes: A61B 17/122 Clamps or clips , e.g. for the umbilical cord for the vas deferens A61F6/206
• CPC Class Codes: A61B 17/30 Surgical pincettes without pivotal connectionsfor holding suture needles or materials A61B17/0483; wound clamps A61B17/08 ; hand-held gripping tools without pivotal connections in general B25B9/02
• CPC Class Codes: A61B 17/3201 Scissors for biopsy A61B10/02
• CPC Class Codes: A61B 17/3211 Surgical scalpels, knives; Accessories therefor
• CPC Class Codes: A61B 2017/0084 low friction A61B2017/00853 takes precedence

Abstract

Providing a ceramic-coated medical appliance quite excellent in insulating performance which has no negative effects on tissues or cells of an organism subjected to surgery; a ceramic-coated genetic control needle which has no risk of breaking during use nor no unfavorable effects, such as destruction or tear-off, on sliced tissues or tissue areas around the needle at site of penetration into a lesion and which cuts off a cell nucleus or injects an immunological solution into the nucleus without causing any negative effects on tissues around the penetrated needle; and a fabrication method for the same.

Claims

1. A ceramic-coated medical appliance or biopsy appliance wherein at least a metal portion directly contacting an organism is coated with an insulating ceramic film having a resistance ρ

of at least 10⁵ Ω

·

m.

2. A ceramic-coated medical appliance or biopsy appliance as claimed in claim 1, wherein the ceramic film has a thickness of 0.05 to 5.0 μ

m.

3. A ceramic-coated medical appliance or biopsy appliance as claimed in claim 1, wherein the ceramic film comprises at least one selected from the group consisting of nitrides, carbides or oxides of Al, B, Si, Cr and Ti.

4. A ceramic-coated medical appliance as claimed in claim 1, wherein the medical appliance is any one of biopsy forceps, forceps, surgical scissors and a surgical knife.

5. A ceramic-coated medical appliance as claimed in claim 1, characterized in that the ceramic-coated medical appliance is any one of an injection needle, puncture needle and suture needle.

6. A ceramic-coated medical needle as claimed in claim 5, characterized in that the insulating ceramic film of a resistance ρ

of 10⁵ Ω

·

m or more is formed on a part or the whole of a surface of the needle.

7. A ceramic-coated medical needle as claimed in claim 6, wherein the ceramic film has a thickness of 0.05 to 5.0 μ

m.

8. A ceramic-coated medical needle as claimed in claim 6, wherein the ceramic film comprises at least one selected from the group consisting of nitrides, carbides or oxides of Al, B, Si, Cr and Ti.

9. A ceramic-coated medical needle as claimed in claim 6, wherein a substrate metal of the coated needle is stainless steel or high tension steel.

10. A ceramic-coated medical needle as claimed in claim 6, characterized in that a ceramic-coated area of the needle is a part or the whole of an outer surface thereof and a portion of an inner surface thereof that is 1 mm inward from a tip of the needle.

11. A ceramic-coated medical needle as claimed in claim 10, wherein the ceramic film has a thickness of 0.05 to 5.0 μ

m.

12. A ceramic-coated medical needle as claimed in claim 10, wherein the ceramic film comprises at least one selected from the group consisting of nitrides, carbides or oxides of Al, B, Si, Cr and Ti.

13. A ceramic-coated medical needle as claimed in claim 10, wherein a substrate metal of the coated needle is stainless steel or high tension steel.

14. A ceramic-coated genetic control needle as claimed in claim 1, wherein the biopsy appliance is a genetic control needle.

15. A ceramic-coated genetic control needle as claimed in claim 14, wherein a ceramic-coated area of the metal needle is at least a portion of a surface thereof that contacts a cell nucleus in tissue of an organism.

16. A ceramic-coated genetic control needle as claimed in claim 14, wherein the coated needle has a diameter of 0.0005 to 0.5 mm.

17. A ceramic-coated genetic control needle as claimed in claim 14, , wherein the ceramic film comprises at least one selected from the group consisting of nitrides, oxides or carbides of Al, B, Si, Cr and Ti.

18. A ceramic-coated genetic control needle as claimed in claim 14, characterized in that a ceramic-coated area of an outer surface of the metal needle is at least a portion thereof that contacts tissue of an organism, whereas a ceramic-coated area of an inner surface of the needle is at least a portion thereof that contacts a cell nucleus in the tissue of the organism.

19. A ceramic-coated genetic control needle as claimed in claim 18, characterized in that the coverage of the insulating ceramic film on the inner surface of the metal needle extends 10 μ

m or more from a tip of the metal needle.

20. A ceramic-coated genetic control needle as claimed in claim 18, wherein the ceramic film has a thickness of 0.05 to 5.0 μ

m.

21. A ceramic-coated genetic control needle as claimed in claim 18, , wherein the ceramic film comprises at least one selected from the group consisting of nitrides, carbides or oxides of Al, B, Si, Cr and Ti.

22. A ceramic-coated genetic control needle as claimed in claim 18, wherein a substrate metal of the needle is stainless steel or high tension steel.

23. A ceramic-coated genetic control needle as claimed in claim 18, wherein the needle has a diameter φ

of 0.0005 to 0.5 mm.

24. A ceramic-coated genetic control needle as claimed in claim 14, characterized in that a ceramic-coated area of the metal needle is at least a respective portion of an outer and an inner surface thereof that contacts a cell nucleus in tissue of an organism, and that the ceramic film has an arithmetic mean surface roughness Ra of 1.5 μ

m or less.

25. A ceramic-coated genetic control needle as claimed in claim 24, wherein the coverage of the insulating ceramic film on the inner surface extends at least 10 μ

m from a tip of the needle.

26. A ceramic-coated genetic control needle as claimed in claim 24, wherein the ceramic film has a thickness of 0.05 to 5.0 μ

m.

27. A ceramic-coated genetic control needle as claimed in claim 24, wherein the ceramic film comprises at least one selected from the group consisting of nitrides, carbides or oxides of Al, B, Si, Cr and Ti.

28. A ceramic-coated genetic control needle as claimed in claim 24, wherein a substrate metal of the needle is stainless steel or high tension steel.

29. A ceramic-coated genetic control needle as claimed in claim 24, wherein the needle has a diameter φ

of 0.0005 to 0.5 mm.

30. A fabrication method for ceramic-coated medical appliance or biopsy appliance wherein an insulating ceramic coating film is formed by dry plating at least on a metal portion of a metallic medical appliance or biopsy appliance that directly contacts an organism.

31. A fabrication method for ceramic-coated medical appliance or biopsy appliance as claimed in claim 30, characterized in that 5 to 500 sccm of O₂ is introduced in a coating atmosphere in the latter stage of the dry plating process, thereby offering a ceramic-coated medical appliance or biopsy appliance having excellent insulating performance, adhesion and wear resistance and featuring a resistance ρ

of 10⁵ Ω

·

m or more at least at a top surface of the ceramic film.

32. A fabrication method for ceramic-coated medical appliance or biopsy appliance as claimed in claim 30, wherein the top surface of the ceramic film has a resistance ρ

of 10⁹ Ω

·

m or more.

33. A fabrication method for ceramic-coated medical appliance or biopsy appliance as claimed in claim 30, characterized in that the ceramic film comprises at least one selected from the group consisting of nitrides, oxides or carbides of Al, B, Si, Cr and Ti.

34. A fabrication method for ceramic-coated medical appliance as claimed in claim 30, characterized in that the medical appliance is any one of biopsy forceps, forceps, surgical scissors and a surgical knife.

35. A fabrication method for ceramic-coated medical appliance as claimed in claim 30, characterized in that the medical appliance is an injection needle or puncture needle.

36. A fabrication method for ceramic-coated medical needle as claimed in claim 35, wherein the metal needle is set in parallel with an approaching direction of deposition particles as presenting a tip thereof against the approaching deposition particles and the ceramic film is formed at least on the tip portion of the needle by dry plating.

37. A fabrication method for ceramic-coated medical needle as claimed in claim 36, wherein the ceramic film is an insulating ceramic film having a resistance ρ

of 10⁵ Ω

·

m or more.

38. A fabrication method for ceramic-coated medical needle as claimed in claim 36, wherein the ceramic film has a thickness of 0.05 to 5.0 μ

m.

39. A fabrication method for ceramic-coated medical needle as claimed in claim 36, wherein the ceramic film comprises at least one selected from the group consisting of nitrides, carbides or oxides of Al, B, Si, Cr and Ti.

40. A fabrication method for ceramic-coated medical needle as claimed in claim 36, wherein a substrate metal of the coated needle is stainless steel or high tension steel.

41. A fabrication method for ceramic-coated medical needle as claimed in claim 35, wherein the insulating ceramic film is formed by magnetron sputtering process using, as a sputter target, at least one selected from the group consisting of nitrides, carbides or oxides of Al, B, Si, Cr and Ti while preventing abnormal discharge by disposing a high-plasma atmosphere forming magnet and an RF device around the target, thereby overlaying the ceramic film on a part or the whole of an outer surface of the needle and on a portion of an inner surface thereof at least 1 mm inward from a tip of the needle.

42. A fabrication method for ceramic-coated medical needle as claimed in claim 41, wherein two of the sputter targets are disposed for forming the insulating ceramic film based on a W-cathode system.

43. A fabrication method for ceramic-coated medical needle as claimed in claim 41, characterized in that the metal needle is set in parallel with an approaching direction of deposition particles as presenting its tip against the approaching deposition particles.

44. A fabrication method for ceramic-coated medical needle as claimed in claim 41, wherein the supply of reaction gas is suspended in an initial stage of the magnetron sputtering process.

45. A fabrication method for ceramic-coated genetic control needle appliance as claimed in claim 30, wherein the biopsy appliance is a genetic control needle.

46. A fabrication method for ceramic-coated genetic control needle as claimed in claim 45, wherein the metal needle is set in parallel with an approaching direction of deposition particles as presenting a tip thereof against the approaching deposition particles, and wherein the insulating ceramic film having a resistance ρ

of 10⁵ Ω

·

m or more is formed at least on the tip portion of the needle by dry plating with an interior of the needle maintained at higher vacuum than the outside thereof through differential-pressure evacuation.

47. A system for fabricating a ceramic-coated genetic control needle comprising a magnetron sputtering apparatus, a sample holder and a differential-pressure high-vacuum chamber in a vacuum vessel of a dry plating system, wherein a metal needle as a coating object is set on the sample holder as positioned in parallel with an approaching direction of deposition particles and presenting a tip thereof against the approaching deposition particles, and wherein a trailing end of the needle is connected with the differential-pressure high-vacuum chamber via a tube for maintaining an interior of the metal needle at higher vacuum than outside thereof by differential pressure vacuum effect while an insulating ceramic film is formed on an outer and an inner surface of the metal needle.