Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2
First Claim
1. A method of inducing angiogenesis in a cell or tissue, said method comprising:
- applying an electromagnetic field to the cell or tissue under conditions effective to induce angiogenesis.
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Abstract
The present invention relates to a method of inducing angiogenesis in a cell or tissue by applying an electromagnetic field to the cell or tissue under conditions effective to induce angiogenesis. Also disclosed is a method of treating an ischemic condition in a patient by applying an electromagnetic field to ischemic tissue in a patient under conditions effective to treat the ischemic condition by inducing angiogenesis. A method of tissue engineering is also disclosed. This method involves providing a tissue scaffold and subjecting the tissue scaffold to an electromagnetic field under conditions effective to form a vascularized tissue scaffold. Further disclosed is a method of inducing activity of angiogenic growth factors by applying an electromagnetic field to a cell or tissue under conditions effective to induce activity of an angiogenic growth factor.
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Citations
30 Claims
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1. A method of inducing angiogenesis in a cell or tissue, said method comprising:
applying an electromagnetic field to the cell or tissue under conditions effective to induce angiogenesis. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A method of treating an ischemic condition in a patient, said method comprising:
applying an electromagnetic field to ischemic tissue in a patient under conditions effective to treat the ischemic condition by inducing angiogenesis. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
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22. A method of tissue engineering comprising:
providing a tissue scaffold, and subjecting the tissue scaffold to an electromagnetic field under conditions effective to form a vascularized tissue scaffold. - View Dependent Claims (23, 24)
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25. A method of inducing activity of angiogenic growth factors, said method comprising:
applying an electromagnetic field to a cell or tissue under conditions effective to induce activity of an angiogenic growth factor. - View Dependent Claims (26, 27, 28, 29, 30)
Specification