Biochip for proteomics applications
First Claim
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1. An array device comprising:
- a substrate having a surface;
one or more binding molecules on said substrate surface; and
one or more instigators, said one or more instigators each comprising (a) a single stranded DNA or RNA or PNA compliment to one or more of said binding molecules and (b) a protein-binding moiety, said protein-binding moiety is specific for a protein.
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Abstract
Arrays of binding molecules/instigators useful for the simultaneous detection of a plurality of proteins, which are the expression products, or fragments thereof, of a cell, or population of cells in an organism are provided. Methods of both making and using the arrays are also disclosed. The arrays are particularly useful for various proteomics applications including assessing patterns of protein expression and modification in cells and can be useful for biowarfare agents detection.
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Citations
6 Claims
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1. An array device comprising:
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a substrate having a surface;
one or more binding molecules on said substrate surface; and
one or more instigators, said one or more instigators each comprising (a) a single stranded DNA or RNA or PNA compliment to one or more of said binding molecules and (b) a protein-binding moiety, said protein-binding moiety is specific for a protein. - View Dependent Claims (2, 3, 4, 5, 6)
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Specification