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Expansion of renewable stem cell populations using modulators of PI 3-kinase

  • US 20050054103A1
  • Filed: 03/04/2004
  • Published: 03/10/2005
  • Est. Priority Date: 03/07/2003
  • Status: Abandoned Application
First Claim
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1. A method of ex vivo expanding and inhibiting differentiation of a population of stem cells, the method comprising:

  • (a) providing the cells ex vivo with conditions for cell proliferation;

    (b) ex vivo providing the cells with an effective concentration of a modulator of PI 3-kinase activity, said modulator selected capable of downregulating a PI 3-kinase activity or an expression of a gene encoding a PI 3-kinase;

    thereby ex vivo expanding and inhibiting differentiation of the population of stem cells.

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