Optimized Fc variants and methods for their generation
First Claim
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1. A variant protein comprising an Fc variant of a wild-type Fc polypeptide, said Fc variant comprising at least one amino acid modification in the Fc region of said wild-type Fc polypeptide, wherein said variant protein exhibits altered binding to an Fcγ
- R as compared to the wild-type Fc polypeptide.
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Abstract
The present invention relates to optimized Fc variants, methods for their generation, and antibodies and Fc fusions comprising optimized Fc variants.
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Citations
37 Claims
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1. A variant protein comprising an Fc variant of a wild-type Fc polypeptide, said Fc variant comprising at least one amino acid modification in the Fc region of said wild-type Fc polypeptide, wherein said variant protein exhibits altered binding to an Fcγ
- R as compared to the wild-type Fc polypeptide.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 24, 32, 33, 34, 35, 36, 37)
- 21. A variant protein comprising an Fc variant of a wild-type Fc polypeptide, said Fc variant comprising at least one amino acid modification in the Fc region of said wild-type Fc polypeptide, wherein said Fc variant modulates effector function as compared to the parent Fc polypeptide.
Specification