Method and system for treatment of atrial fibrillation and other cardiac arrhythmias

• US 20050054918A1
• Filed: 09/02/2004
• Published: 03/10/2005
• Est. Priority Date: 09/04/2003
• Status: Abandoned Application

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Sra, Jasbir S.
• Application Number:
  US10/932,487
• Publication Number:
  US 20050054918A1
• Time in Patent Office: Days
• US Class Current: 600/427
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61B 2034/105 Modelling of the patient, e.g. for ligaments or bones
• CPC Class Codes: A61B 2090/364 Correlation of different images or relation of image positions in respect to the body
• CPC Class Codes: A61B 34/20 Surgical navigation systems; Devices for tracking or guiding surgical instruments, e.g. for frameless stereotaxis
• CPC Class Codes: A61B 6/032 Transmission computed tomography [CT]
• CPC Class Codes: A61B 6/12 Arrangements for detecting or locating foreign bodies
• CPC Class Codes: A61B 6/466 adapted to display 3D data
• CPC Class Codes: A61B 6/503 for diagnosis of the heart
• CPC Class Codes: A61B 6/504 for diagnosis of blood vessels, e.g. by angiography
• CPC Class Codes: A61B 6/541 involving acquisition triggered by a physiological signal
• CPC Class Codes: A61B 90/36 Image-producing devices or illumination devices not otherwise provided for

Abstract

A method is provided for treatment of a heart arrhythmia such as atrial fibrillation that includes obtaining cardiac image data using a digital imaging system, generating a 3D model of a cardiac chamber and surrounding structures from such cardiac image data, registering the 3D model with an interventional system, visualizing this registered 3D model on the interventional system, positioning a catheter apparatus within the cardiac chamber, visualizing the catheter apparatus over the registered 3D model of the cardiac chamber upon the interventional system, navigating the catheter apparatus within the cardiac chamber utilizing this registered 3D model, and delivering biological material through the catheter apparatus to heart tissue at select locations within the cardiac chamber. Preferably, the biological material are transplanted cells or antibodies. In another aspect of the invention, a system for treatment of heart arrhythmias is provided that has a digital imaging system to obtain cardiac image data, an image generation system to generate a 3D model of a cardiac chamber and its surrounding structures from this cardiac image data, a workstation to register the 3D model onto an interventional system so that the registered 3D model can be visualized upon the interventional system, and a catheter apparatus to deliver biological material such as transplanted cells or antibodies to heart tissue within this cardiac chamber at certain select locations, the catheter apparatus being visualized upon the interventional system over the registered 3D model.

Claims

1. A method for treatment of a heart arrhythmia comprising:

obtaining cardiac image data from a digital imaging system;

generating a 3D model of a cardiac chamber and surrounding structures from the cardiac image data;

registering the 3D model with an interventional system;

visualizing the registered 3D model upon the interventional system;

positioning a catheter apparatus within the cardiac chamber;

visualizing the catheter apparatus over the registered 3D model upon the interventional system;

navigating the catheter apparatus within the cardiac chamber utilizing the registered 3D model; and

delivering biological material through the catheter apparatus to heart tissue at select locations.

2. The method of claim 1 wherein the biological material are transplanted cells, whereby the transplanted cells alter electrical impulses at the select locations.

3. The method of claim 2 wherein the transplanted cells are myoblasts.

4. The method of claim 1 wherein the biological material are antibodies, whereby the antibodies alter electrical impulses at the select locations.

5. The method of claim 1 wherein the interventional system is a fluoroscopic system.

6. The method of claim 1 wherein the digital imaging system is a computer tomography (CT) system.

7. The method of claim 1 wherein the heart arrhythmia is atrial fibrillation and wherein the 3D model is of the left atrium and pulmonary veins.

8. The method of claim 1 wherein the catheter apparatus comprises:

a main body having a central lumen adapted to the delivery of biological material; and

a control mechanism coupled to the main body wherein delivery of the biological material from the main body is controlled.

9. A system for treatment of a heart arrhythmia comprising:

a digital imaging system for obtaining cardiac image data;

an image generation system for generating a 3D model of a cardiac chamber and surrounding structures from the cardiac image data;

a workstation for registering the 3D model with an interventional system to visualize the registered 3D model upon the interventional system; and

a catheter apparatus for delivering biological material to heart tissue within the cardiac chamber at select locations, whereby the catheter apparatus is visualized over the registered 3D model upon the interventional system.

10. The system of claim 9 wherein the biological material are transplanted cells, whereby the transplanted cells alter electrical impulses at the select locations.

11. The system of claim 10 wherein the transplanted cells are myoblasts.

12. The system of claim 9 wherein the biological material are antibodies, whereby the antibodies alter electrical impulses at the select locations.

13. The system of claim 9 wherein the interventional system is a fluoroscopic system.

14. The system of claim 9 wherein the digital imaging system is a computer tomography (CT) system.

15. The system of claim 9 wherein the heart arrhythmia is atrial fibrillation and wherein the 3D model is of the left atrium and pulmonary veins.

16. The system of claim 9 wherein the catheter apparatus comprises:

a main body having a central lumen adapted to the delivery of biological material; and

a control mechanism coupled to the main body wherein delivery of the biological material from the main body is controlled.