Novel human protease inhibitor proteins and polynucleotides encoding the same

• US 20050059816A1
• Filed: 07/29/2004
• Published: 03/17/2005
• Est. Priority Date: 09/27/2000
• Status: Abandoned Application

• Current Assignee: Boris Nepomnichy, Carl Johan Friddle, Erin Hilbun, Gregory Donoho, Turner C. Alexander Jr, Walke D. Wade, Yi Hu
• Original Assignee: Boris Nepomnichy, Carl Johan Friddle, Erin Hilbun, Gregory Donoho, Turner C. Alexander Jr, Walke D. Wade, Yi Hu
• Inventors: Hu, Yi, Walke, D. Wade, Friddle, Carl Johan, Hilbun, Erin, Nepomnichy, Boris, Donoho, Gregory, Turner, C. Alexander Jr.
• Application Number:
  US10/901,803
• Publication Number:
  US 20050059816A1
• Time in Patent Office: Days
• US Class Current: 536/23.200
• CPC Class Codes: A61K 38/00 Medicinal preparations containing peptides peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00
• CPC Class Codes: C07K 14/81 Protease inhibitors
• CPC Class Codes: C07K 14/8107 Endopeptidase (E.C. 3.4.21-99) inhibitors
• CPC Class Codes: C07K 14/811 Serine protease (E.C. 3.4.21) inhibitors
• CPC Class Codes: H04L 25/0204 of multiple channels
• CPC Class Codes: H04L 27/2647 Arrangements specific to the receiver only equalisation H04L27/01

Abstract

Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.

Claims

1. An isolated nucleic acid molecule comprising at least 24 contiguous bases of nucleotide sequence first disclosed in SEQ ID NO:

1.

2. An isolated nucleic acid molecule comprising a nucleotide sequence that:

(1) encodes the amino acid sequence shown in SEQ ID NO;

2; and

(2) hybridizes under stringent conditions to the nucleotide sequence of SEQ ID NO;

1 or the complement thereof.

3. An isolated nucleic acid molecule comprising a nucleotide sequence encoding an amino acid sequence drawn from the group consisting of SEQ ID NOS:

2 and 4.

4. An isolated nucleic acid molecule comprising a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:

2.

5. An isolated nucleic acid molecule comprising a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:

4.

6. An isolated nucleic acid molecule comprising a nucleotide sequence that:

(a) encodes the amino acid sequence shown in SEQ ID NO;

7; and

(b) hybridizes under stringent conditions to the nucleotide sequence of SEQ ID NO;

6 or the complement thereof.

7. An isolated nucleic acid molecule comprising a nucleotide sequence encoding the amino acid sequence shown in SEQ ID NO:

7.