Method and apparatus for localized drug delivery

• US 20050059930A1
• Filed: 09/16/2003
• Published: 03/17/2005
• Est. Priority Date: 09/16/2003
• Status: Abandoned Application

• Current Assignee: Michi Garrison, Peter F. Campbell, Steve Salmon
• Original Assignee: Michi Garrison, Peter F. Campbell, Steve Salmon
• Inventors: Salmon, Steve, Campbell, Peter F., Garrison, Michi
• Application Number:
  US10/664,171
• Publication Number:
  US 20050059930A1
• Time in Patent Office: Days
• US Class Current: 604/101.40
• CPC Class Codes: A61M 2025/0004 having two or more concentrically arranged tubes for forming a concentric catheter system
• CPC Class Codes: A61M 2025/1015 having two or more independently movable balloons where the distance between the balloons can be adjusted, e.g. two balloon catheters concentric to each other forming an adjustable multiple balloon catheter system
• CPC Class Codes: A61M 2025/1052 for temporarily occluding a vessel for isolating a sector
• CPC Class Codes: A61M 25/0032 characterized by at least one unconventionally shaped lumen, e.g. polygons, ellipsoids, wedges or shapes comprising concave and convex parts
• CPC Class Codes: A61M 25/1011 Multiple balloon catheters

Abstract

A catheter system for localized administration of agents through the wall of a blood vessel is provided. Various catheter system constructions which use at least two expandable occluding elements to create the localized site are provided. The catheter system may include a catheter with a variable stiffness along its length. The catheter system may also include a hollow guide wire which is coupled to an expandable occluding element.

Claims

1. A catheter system for creating an isolated blood vessel segment comprising:

a first catheter and a second catheter, each having a proximal and a distal end,

said first catheter having a first expandable occlusion device associated therewith,

said second catheter having a second expandable occlusion device associated therewith and being adapted to expand said second occlusion device distally of the first occlusion device on the first catheter,

said second catheter being slidably housed within a first lumen in said first catheter such the distance between said first and second occlusion device may be varied,

the occlusion devices being expandable to engage a wall of a blood vessel thereby substantially isolating an interior segment of a desired extent between said first and second occlusion devices, and at least one of said catheters having a relatively stiff proximal region, a softer intermediate region and a still softer distal region.

3. The catheter system of claim 1 wherein the system is provided with a pressure regulator.

4. The catheter system of claim 1 wherein said second catheter is spaced from the inner wall of said first catheter to create a coaxial lumen surrounding a centrally located lumen.

5. The catheter system of claim 1 wherein said second catheter is provided with three lumens.

6. The catheter system of claim 4 wherein said centrally located lumen is provided with an axially extending tube.

2. A catheter system for creating an isolated blood vessel segment comprising:

a catheter and a guide wire each having a proximal and a distal end,

said catheter having a first expandable occlusion device associated therewith,

said guide wire having a second expandable occlusion device associated therewith and being adapted to expand said second occlusion device distally of the first occlusion device on the first catheter,

said catheter being slidably mounted on said guide wire,

the occlusion devices being expandable to engage a wall of a blood vessel thereby substantially isolating an interior segment of a desired extend between said first and second occlusion devices.