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Monitoring circadian activity

  • US 20050059977A1
  • Filed: 03/31/2004
  • Published: 03/17/2005
  • Est. Priority Date: 03/31/2003
  • Status: Abandoned Application
First Claim
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1. A method for identifying at least one agent which modulates a preselected biological condition controlled by the circadian clock in a subject comprising a) inserting a monitoring device into, or in close proximity to the pineal, causing little or no tissue damage to the non-pineal tissue during the inserting;

  • b) monitoring the chemical output of the pineal and monitoring a preselected biological condition of a first subject; and

    , c) monitoring the chemical output of the pineal and monitoring the same preselected biological condition as in step b) in a second subject after contacting the second subject with the at least one agent;

    wherein an alteration in the chemical output of the pineal and in the preselected biological condition in the second subject as compared to the chemical output of the pineal and preselected biological condition in the first subject identifies at least one agent which modulates a preselected biological condition controlled by the circadian clock.

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