Covered stent with biologically active material
First Claim
Patent Images
1. A composite device for delivery of bioactive agents associated therewith to a site of implantation of said device comprising:
- a first polymeric liner;
a second polymeric liner;
an intermediate structural member interposed between said first and said second polymeric liners, said intermediate structural member being defined by solid segments and openings therebetween such that the first liner can be bonded to the second liner through said openings to form at least one pocket about said solid segments; and
a bioactive agent located within said pocket about said solid segments of said intermediate structural member.
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Accused Products
Abstract
A composite device provides for the delivery of bioactive agents associated therewith. The device includes a first polymeric liner and a second polymeric liner bonded to the first liner. The device further includes an intermediate structural member interposed between the liner, which is defined by solid segments and openings between the solid segments. The liners are joined through the openings to form at least one pocket about the solid segments. A bioactive agent is located within the pockets about the solid segments of the intermediate structural member.
331 Citations
47 Claims
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1. A composite device for delivery of bioactive agents associated therewith to a site of implantation of said device comprising:
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a first polymeric liner;
a second polymeric liner;
an intermediate structural member interposed between said first and said second polymeric liners, said intermediate structural member being defined by solid segments and openings therebetween such that the first liner can be bonded to the second liner through said openings to form at least one pocket about said solid segments; and
a bioactive agent located within said pocket about said solid segments of said intermediate structural member. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A composite intraluminal device for delivery of bioactive agents associated therewith to a site of implantation of said device comprising:
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an elongate stent having a generally cylindrical tubular body defined by solid segments and openings between said solid segments, said tubular body defining an inner surface and an opposed outer surface;
a first polymeric liner positioned about said inner surface of said tubular body;
a second polymeric liner positioned about said outer surface of said tubular body;
said second polymeric liner being joined to said first liner through said stent openings to form at least one pocket about said solid segments; and
a bioactive agent located within said pocket about said solid segments of said tubular body.
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28. A method of making an implantable composite device for delivery of bioactive agents associated therewith to a site of implantation of said device, said method comprising:
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providing an implantable prosthetic stent having a generally cylindrical tubular body defined by solid segments and spaces therebetween, said tubular body defining an inner surface and an opposed outer surface;
applying a first polymeric liner to said inner surface;
applying a second polymeric liner to said outer surface;
joining said first and said second polymeric liners through said spaces between said stent segments to form a reservoir pocket adjacent to said solid segments; and
filling said reservoir pocket with a bioactive agent for delivery of said bioactive agent to the site of implantation of said device. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40)
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41. A method of making an implantable composite device for delivery of bioactive agents associated therewith to a site of implantation of said device, said method comprising:
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providing a first polymeric liner;
providing a second polymeric liner;
interposing an intermediate structural member between said first and second polymeric liners, said intermediate structural member being defined by solid segments and openings therebetween;
joining said first and second polymeric liners through said openings between said solid segments to form reservoir pockets adjacent to said solid segments; and
filling said reservoir pockets with a bioactive agent for delivery of said bioactive agent to the site of implantation of said device.
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42. A method for treating a lumen in a body, said method comprising:
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inserting a generally cylindrical implantable composite device for delivery of bioactive agents incorporated therewith into said lumen, the device comprising a first polymeric liner;
a second polymeric liner;
an intermediate structural member interposed between said first and second liners, said intermediate structural member being defined by solid segments and openings therebetween such that the first liner can be bonded to the second liner through said openings to form at least one pocket about said solid segments; and
a bioactive agent located within said pocket; and
affixing said implantable composite device to said lumen such that it will stay where positioned. - View Dependent Claims (43, 44, 45, 46)
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47. A method for treating a lumen in a body, said method comprising:
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inserting an implantable composite device for delivery of bioactive agents incorporated therewith into said lumen, the device comprising an elongate stent having a generally cylindrical tubular body defined by solid segments and openings between said solid segments, said tubular body defining an inner surface and an opposed outer surface;
a first polymer liner positioned about said inner surface of said tubular body;
a second polymer liner positioned about said outer surface of said tubular body;
said second polymer liner being joined to said first polymer liner through said stent openings to form a pocket about said solid segments; and
a bioactive agent located within said pocket about said solid segments of said tubular body; and
affixing said implantable composite device to said lumen such that it will stay where positioned.
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Specification