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Separation system, components of a separation system and methods of making and using them

  • US 20050061745A1
  • Filed: 08/06/2004
  • Published: 03/24/2005
  • Est. Priority Date: 06/26/2002
  • Status: Abandoned Application
First Claim
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1. A chromatographic system comprising:

  • a pumping system;

    a chromatographic column and detector array;

    a fraction collector system; and

    a controller;

    said chromatographic column and detector array including a plurality of chromatographic columns;

    each of said chromatographic columns having a diameter size over 10 mm;

    each of said chromatographic columns containing a corresponding one of a plurality of polymeric plugs without substantially inhomogeneous pore sizes caused by exotherms;

    each of said polymeric plugs having the same characteristics, whereby said chromatographic columns separate sample in a similar manner;

    a source of solvent;

    said pumping system being arranged to supply solvent from the source of solvent to the chromatographic column and detector array under the control of the controller wherein effluent flows into the collector system from the chromatographic column and detector array under the control of the controller;

    said controller being connected to receive signals from detectors in the chromatographic column and detector array indicating bands of solute and to activate the collector accordingly.

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