Transscleral delivery
First Claim
1. A method for treating wet age-related macular degeneration in a human, the method comprising administering transsclerally to an eye of the human an amount of rapamycin effective to treat wet age-related macular degeneration.
2 Assignments
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Accused Products
Abstract
Diseases associated with the tissues in the posterior segment of the eye can be effectively treated by administering therapeutic agents transsclerally to those tissues. Compositions, devices, and methods for delivering therapeutic agents so that they cross the sclera and reach these tissues include injecting solutions or suspensions adjacent to or within the sclera and implanting solid structures containing the therapeutic agent adjacent to or within the sclera. These methods may be used for administering rapamycin or related compounds to treat choroidal neovascularization associated with age-related macular degeneration.
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Citations
70 Claims
- 1. A method for treating wet age-related macular degeneration in a human, the method comprising administering transsclerally to an eye of the human an amount of rapamycin effective to treat wet age-related macular degeneration.
- 24. A method for treating, inhibiting or preventing angiogenesis in the eye of a subject, the method comprising administering transsclerally to the eye an amount of a therapeutic agent effective to treat, inhibit or prevent angiogenesis.
- 57. A transscleral rapamycin drug delivery system for delivery of rapamycin to the posterior segment of a human eye, comprising a polymer implant containing rapamycin, wherein the drug delivery system when placed proximate to the outer scleral surface of the human eye delivers transsclerally an amount of rapamycin effective to treat, prevent, inhibit, delay the onset of, or cause regression of choroidal neovascularization in human.
Specification