Novel human bmcc1 gene

• US 20050064413A1
• Filed: 08/23/2002
• Published: 03/24/2005
• Est. Priority Date: 08/24/2001
• Status: Active Grant

• Current Assignee: Chiba-Prefecture, Hisamitsu Pharmaceutical Company Incorporated
• Original Assignee: Hisamitsu Pharmaceutical Company Incorporated
• Inventors: Sakaki, Yoshiyuki, Hattori, Masahira, Nakagawara, Akira
• Granted Patent: US 7,238,796 B2
• Time in Patent Office: Days
• US Class Current: 435/6
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: C07K 14/47 from mammals

Abstract

Human BMCC1 protein having an amino acid sequence set forth in SEQ ID NO:1 in the Sequence Listing and its variant protein, as well as human BMCC1 gene having a base sequence set forth in SEQ ID NO:2 in the Sequence Listing and its variant gene.

Claims

1. A protein comprising an amino acid sequence set forth in SEQ ID NO:

1 in the Sequence Listing or a salt thereof.

4. A nucleic acid encoding the protein according to claim 1 or a partial peptide thereof.

6. An isolated nucleic acid capable of hybridizing to the nucleic acid according to claim 4 or a complementary nucleic acid thereof under stringent conditions.

7. The nucleic acid according to claim 6, wherein the protein encoded by the nucleic acid is provided with apoptosis-inducing activity.

9. The nucleic acid according to any of claims 4-8, wherein the nucleic acid has enhancement in expression in neuroblastomas with favorable prognosis based on comparison between neuroblastomas with favorable prognosis and neuroblastomas with unfavorable prognosis.

2. A protein comprising a deletion, a substitution, an insertion or an addition of one or more amino acids in an amino acid sequence set forth in SEQ ID NO:

1 in the Sequence Listing or a salt thereof.

3. The protein or a salt thereof according to claim 2, wherein the protein has the amino acid sequence and is provided with apoptosis-inducing activity.

5. A nucleic acid comprising a base sequence set forth in SEQ ID NO:

2.

8. A nucleic acid comprising a portion of a base sequence set forth in SEQ ID NO:

2.