Method of formulating a pharmaceutical composition
First Claim
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1. A method of formulating a pharmaceutical composition comprising:
- comparing parameters of at least one pharmaceutical and a plurality of compounds, wherein the parameters comprise at least log(P) and molecular weight;
choosing at least one model compound from the plurality of compounds for each pharmaceutical;
providing at least one model compound-excipient formulation comprising at least one model compound and at least one excipient;
measuring the diffusion of a model compound of at least one model compound-excipient formulation across at least one membrane;
choosing a model compound-excipient formulation based on the measured model compound diffusion; and
combining components comprising the at least one pharmaceutical and the excipient package of the chosen model compound-excipient formulation.
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Abstract
A method of formulating a pharmaceutical composition utilizes at least one model compound as a substitute for at least one pharmaceutical.
34 Citations
25 Claims
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1. A method of formulating a pharmaceutical composition comprising:
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comparing parameters of at least one pharmaceutical and a plurality of compounds, wherein the parameters comprise at least log(P) and molecular weight;
choosing at least one model compound from the plurality of compounds for each pharmaceutical;
providing at least one model compound-excipient formulation comprising at least one model compound and at least one excipient;
measuring the diffusion of a model compound of at least one model compound-excipient formulation across at least one membrane;
choosing a model compound-excipient formulation based on the measured model compound diffusion; and
combining components comprising the at least one pharmaceutical and the excipient package of the chosen model compound-excipient formulation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Current Assignee3M Innovative Properties Company (3M Company)
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Original Assignee3M Innovative Properties Company (3M Company)
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InventorsRakow, Neal A., Roscoe, Stephen B., McIntosh, Lester H. III, Husberg, Michael L.
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Application NumberUS10/669,390Publication NumberTime in Patent OfficeDaysField of SearchUS Class Current514/1CPC Class CodesA61K 9/7023 Transdermal patches and sim...G01N 33/5082 Supracellular entities, e.g...
