Stable pharmaceutical compositions of 2-aza-bicyclo [3.3.0]-octane-3-carboxylic acid derivatives
First Claim
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1. A stable pharmaceutical composition comprising:
- an intimate admixture including a 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivative and an effective amount of a lubricant to stabilize the composition; and
an external excipient.
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Abstract
A stable composition of a 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivative and a method for its preparation are described. The stable composition includes an intimate admixture of the derivative and a stabilizing effective amount of a lubricant. The stable composition further includes an external excipient. A method of preparing the stable composition includes forming an intimate admixture of the derivative and a lubricant and then blending the intimate admixture with at least one excipient. Preferably the final blend is transformed into solid unit dosage form.
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Citations
38 Claims
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1. A stable pharmaceutical composition comprising:
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an intimate admixture including a 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivative and an effective amount of a lubricant to stabilize the composition; and
an external excipient. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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32. A method for preparing a stable pharmaceutical composition comprising:
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forming an intimate admixture including a 2-aza-bicyclo[3.3.0]-octane-3-carboxylic acid derivative and a lubricant; and
blending the intimate admixture with an external excipient. - View Dependent Claims (33, 34, 35, 36, 37, 38)
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Specification