Methods for treating disorders using plant extracts
First Claim
1. A method of modulating blood glucose level in a mammal comprising administration of an effective dose of a mildly polar extract of Artemisia.
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Abstract
The present invention provides materials and methods relating to mildly polar fluid extracts of plant materials, such as Artemisia plant species, useful in methods for treating diabetes and methods for modulating the activity of glucagon-like peptide-1 (GLP-1), and in methods for modulating phosphoenol pyruvate carboxykinase (PEPCK) activity in a diabetes-specific manner. The extracts are generally non-toxic and non-mutagenic and may be administered to diabetics with beneficial effect on blood glucose levels. The extracts may also be administered to non-diabetics without deleterious effect. The plants are easily grown with a minimum of time, labor, and cost. Extracts are inexpensively and quickly prepared without the need for fractionation to remove potentially deleterious compounds, and the extracts may be administered to mammals such as humans through various routes, in a variety of forms, and at convenient concentrations.
35 Citations
54 Claims
- 1. A method of modulating blood glucose level in a mammal comprising administration of an effective dose of a mildly polar extract of Artemisia.
- 3. A method of modulating glucagons-like peptide-1 (GLP-1) activity in a mammal comprising administration of an effective dose of a mildly polar extract of Artemisia.
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5. A method of altering the appetite of a mammal comprising administering an effective dose of a mildly polar extract of Artemisia to the mammal.
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6. A method of promoting an ileal brake comprising administering an effective dose of a mildly polar extract of Artemisia to a mammal.
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7. A method of modulating the binding between GLP-1 and the GLP-1 receptor comprising administering an effective dose of a mildly polar extract of Artemisia to a mammal.
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8. A method of modulating α
- -glucosidase activity in a mammal comprising administration of an effective dose of a mildly polar extract of Artemisia.
- 9. A method of modulating insulin resistance in a mammal comprising administering an effective dose of a mildly polar extract of Artemisia.
- 11. A method of modulating the in vivo conversion of glucose to glycogen in a mammal comprising administering an effective dose of a mildly polar extract of Artemisia.
- 13. A method of modulating the expression of insulin receptor substrate-2 (IRS-2) polypeptide in a mammal comprising administering an effective dose of a mildly polar extract of Artemisia.
- 15. A method of modulating insulin-stimulated glucose uptake in a mammal comprising administering an effective dose of a mildly polar extract of Artemisia.
- 17. A method of modulating hepatic glucose output in a mammal comprising administering an effective dose of a mildly polar extract of Artemisia.
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20. (canceled)
- 21. A method of promoting increased cellular energy in non-adipose cells comprising administering an effective dose of a mildly polar extract of Artemisia.
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28. A method of preparing a mildly polar extract of Artemisia comprising the steps of:
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(a) contacting Artemisia with an elicitor; and
(b) extracting the Artemisia with a mildly polar fluid. - View Dependent Claims (29, 30, 31, 32, 33, 34, 35, 36, 37)
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- 45. A pharmaceutical composition comprising an effective dose of a mildly polar extract of Artemisia.
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50. A pharmaceutical composition comprising an effective dose of a compound selected from the group consisting of capillarisin, tetrahydroxy-methoxy flavanone, umbelliferone, sakuranin, trihydroxy-methoxy flavanone and trihydroxy flavanone.
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52. A formulation for treating diabetes in a mammal comprising an Artemisia extract and at least one compound selected from the group consisting of gymnema sylvestre, fenugreek, bitter melon, alpha-lipoic acid, alpha-lipoic acid salts, corosolic acid, ursolic acid, D-pinitol, aloe vera, chromium picolinate, banaba leaf, yacou root, momordica charantia, olive leaf extract, pterocarpus marsupium, salacia reticulata, garlic, hawthorn, phosphatidylserine, omega 3 fatty acids, and resistant starch.
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53. A formulation for weight control in a mammal comprising an Artemisia extract and at least one compound selected from the group consisting of pyruvic acid, pyruvic acid salts, L-carnitine, hydroxycitric acid, ephedrine, caffeine, conjugated linoleic acid, aspirin, alpha-lipoic acid, and alpha-lipoic acid salts.
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54. A formulation for promoting increased cellular energy in non-adipose cells in a mammal comprising an Artemisia extract and at least one compound selected from the group consisting of creatine, creatine monohydrate, a creatine salt, creatine citrate, creatine pyruvate, phosphocreatine, caffeine, alpha-lipoic acid, glucosamine, chondroitin, hydrolyzed collagen, methylsulfonyl-methane, Whey protein, L-glutamine, phosphatidylcholine, choline, a choline salt, phosphatidylserine, beta-hydroxy beta-methylbutyrate, pyruvic acid, pyruvic acid salts, L-carnitine, D-ribose, an amino acid, a branched chain amino acid, S-Adenosylmethionine, taurine, conjugated linoleic acid, alpha-lipoic acid, alpha-lipoic acid salts, and glycerin.
Specification