Microfabricated Fluidic Structures
First Claim
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1. A method of reacting a reagent through a plate having a set of vertical apertures for the passage of at least one substance from a first location to a second location, comprising the steps of:
- providing a plate having a set of vertical apertures arranged in a array of sample cells;
introducing a first reagent in one of said vertical apertures and reacting said first reagent with a second reagent.
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Abstract
A plate for use in mixing and testing materials in the pharmaceutical industry is formed by a method in which an array of sample cells contain a U-shaped structure having two vertical apertures connected by a horizontal passage in a bottom sheet; reagents are drawn in to the vertical passages by capillary action or other forces and react in the horizontal passage. An optional version of the invention includes a relatively large reservoir for containing rinsing fluids.
56 Citations
26 Claims
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1. A method of reacting a reagent through a plate having a set of vertical apertures for the passage of at least one substance from a first location to a second location, comprising the steps of:
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providing a plate having a set of vertical apertures arranged in a array of sample cells;
introducing a first reagent in one of said vertical apertures and reacting said first reagent with a second reagent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. A method for reagent delivery to a surface of a microchannel comprising the steps of:
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a) bringing the reagent into close proximity with the surface by inserting the reagent in a microstructure whose height is a reduced multiple of the reagent'"'"'s diffusion constant;
b) reacting the reagent with the desired surface for a reaction time; and
replenishing the microchannel with new reagent when the concentration of reagent near the surface is reduced below a threshold value. - View Dependent Claims (11, 12)
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13. A method of reacting a reagent through a plate for the passage through a set of apertures of at least one substance from a first location to a second location comprising the steps of:
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providing a plate having a set of vertical apertures arranged in a array of sample cells;
introducing a first reagent in one of said vertical apertures and holding a trailing end of said first reagent at a capillary retention valve. - View Dependent Claims (14, 15, 16, 17)
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18. A method for the delivery of non-homogeneous materials in a fluid to a surface in a microfluidic apparatus comprising the steps of:
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delivering a fluid containing non-homogeneous materials to a specified position in a microfluidic apparatus; and
using an external force to enable the interaction of the non-homogeneous materials with a surface wall of the microfluidic apparatus. - View Dependent Claims (19, 20)
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21. A method of reacting a reagent through a plate for the passage through a set of apertures of at least one substance from a first location to a second location comprising the steps of:
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providing a plate having a set of vertical apertures arranged in a array of sample cells;
introducing a first reagent in one of said vertical apertures and holding a trailing end of said first reagent at a capillary retention valve; and
after a period of time, reacting said first reagent with a second reagent. - View Dependent Claims (22, 23)
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24. A method of metering the delivery of reagents into a microfluidic component comprising the steps of:
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interacting a fluid reservoir with the fluid input of a microfluidic component;
controlling the flow into the device using flow restriction elements in the microfluidic component; and
timing the duration of interaction such that the desired amount of fluid is delivered into the microfluidic component. - View Dependent Claims (25, 26)
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Specification