System and method for correction of intracerebral chemical imbalances
First Claim
1. A method of treating a central nervous system (CNS) disorder, comprising the steps of:
- inserting into a patient'"'"'s body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient'"'"'s CNS with direct access to cerebrospinal fluid (CSF) and so that a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS;
detecting and analyzing brain activity of a patient;
determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF and the detected and analyzed brain activity; and
treating the patient based on the determined chemical imbalance by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity of CSF via the second conduit.
1 Assignment
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Accused Products
Abstract
A method of treating a central nervous system (CNS) disorder, comprises the steps of inserting into a patient'"'"'s body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient'"'"'s CNS with direct access to cerebrospinal fluid (CSF) and a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS in combination with the steps of detecting and analyzing brain activity of a patient and determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF withdrawn from the second reservoir and the detected and analyzed brain activity. Based on the determined chemical imbalance, the patient is treated by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity CSF via the second conduit. A system for treating disorders of the central nervous system (CNS), comprises first and second conduits, wherein, when in an operative position, distal ends of the first and second conduits open into a portion of a patient'"'"'s CNS with direct access to cerebrospinal fluid (CSF) and wherein, when in the operative position, a proximal end of the second conduit opens to drain CSF from the CNS and a first reservoir imlpantable within the patient'"'"'s body and holding material to be introduced to the CNS in combination with a first pump coupled to the first reservoir and the first conduit for introducing the material to the CNS via the first conduit and a brain wave detection unit for detecting and analyzing brain waves of the patient.
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Citations
46 Claims
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1. A method of treating a central nervous system (CNS) disorder, comprising the steps of:
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inserting into a patient'"'"'s body first and second conduits so that distal ends of the first and second conduits open to a portion of the patient'"'"'s CNS with direct access to cerebrospinal fluid (CSF) and so that a proximal end of the first conduit opens into a first reservoir of material to be introduced into the CSF and a proximal end of the second conduit opens to drain CSF withdrawn from the CNS;
detecting and analyzing brain activity of a patient;
determining a chemical imbalance present in the CSF by one of a microassay of a sample of CSF and the detected and analyzed brain activity; and
treating the patient based on the determined chemical imbalance by one of supplying an agent to the CSF via the first conduit and withdrawing a quantity of CSF via the second conduit. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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20. A system for treating disorders of the central nervous system (CNS), comprising:
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first and second conduits, wherein, when in an operative position, distal ends of the first and second conduits open into a portion of a patient'"'"'s CNS with direct access to cerebrospinal fluid (CSF) and wherein, when in the operative position, a proximal end of the second conduit opens to drain CSF from the CNS;
a first reservoir implantable within the patient'"'"'s body and holding a first material to be introduced to the CNS;
a first pump coupled to the first reservoir and the first conduit for introducing the first material to the CNS via the first conduit; and
a brain activity detection unit for detecting and analyzing brain activity of the patient. - View Dependent Claims (21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. An osmotic pump including:
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a plurality of agent reservoirs;
first and second solute chambers;
a semi-permeable membrane separating the first and second solute chambers from one another;
a flexible membrane separating a first one of the agent reservoirs from the first solute chamber; and
a plurality of valves, each of the valves moveable between an open position in which a corresponding one of the agent reservoirs is open to an outlet of the pump and a closed position in which the corresponding one of the agent reservoirs is sealed with respect to the pump outlet. - View Dependent Claims (37, 38, 39)
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40. A system for treating disorders of the central nervous system (CNS), comprising:
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first and second conduits, wherein, when in an operative position, distal ends of the first and second conduits open into a portion of a patient'"'"'s CNS with direct access to cerebrospinal fluid (CSF) and wherein, when in the operative position, a proximal end of the second conduit opens to drain CSF from the CNS;
a first reservoir implantable within the patient'"'"'s body and holding a first material to be introduced to the CNS;
intracranial pressure detecting unit;
a first pump coupled to the first reservoir and the first conduit for introducing the first material to the CNS via the first conduit; and
a brain activity detection unit for detecting and analyzing brain activity of the patient, the brain activity detection unit controlling drainage of CSF based on input from the intracranial pressure detecting unit to maintain intracranial pressure within a predetermined range. - View Dependent Claims (41, 42, 43, 44, 45, 46)
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Specification