Oxyntomodulin for preventing or treating excess weight

• US 20050070469A1
• Filed: 09/09/2002
• Published: 03/31/2005
• Est. Priority Date: 09/07/2001
• Status: Active Grant

• Current Assignee: Imperial Innovations Limited (Imperial College London)
• Original Assignee: Imperial Innovations Limited (Imperial College London)
• Inventors: Ghatei, Mohammad Ali, Small, Caroline Jane, Bloom, Stephen Robert, Dakin, Catherine Louise
• Granted Patent: US 7,666,835 B2
• Time in Patent Office: Days
• US Class Current: 514/4.900
• CPC Class Codes: A61K 38/22 Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin A61K38/33, e.g. corticotropin A61K38/35
• CPC Class Codes: A61K 38/26 Glucagons
• CPC Class Codes: A61K 47/02 Inorganic compounds
• CPC Class Codes: A61K 47/543 Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
• CPC Class Codes: A61K 47/60 the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/0053 Mouth and digestive tract, i.e. intraoral and peroral administration rectal administration A61K9/0031
• CPC Class Codes: A61P 3/04 Anorexiants; Antiobesity agents

Abstract

The present invention relates to compositions and methods for use in the prevention or treatment of excess weight in a mammal. The compositions comprise oxyntomodulin which is shown to reduce food intake.

Claims

6. A method for the prevention or treatment of excess weight in a mammal, comprising administering a composition comprising oxyntomodulin, or an analogue, salt, conjugate, or chemically modified version thereof, to said mammal in an amount effective to prevent or treat excess weight in said mammal.

1. The method of claim 6 wherein said composition comprising oxyntomodulin is administered to said mammal by oral, parenteral, mucosal, rectal subcutaneous or transdermal administration.

2. The method of claim 1, wherein said composition comprising oxyntomodulin is administered to said mammal by inhalation or by buccal, sublingual or nasal administration.

3. The method of claim 6, wherein said composition comprising oxyntomodulin is administered to said mammal in the presence of a metal.

4. The method of claim 6, wherein said composition comprising oxyntomodulin, is administered to said mammal in liquid, solid or semi-solid form.

5. The method of claim 6, wherein said mammal is a human.

7. The method of claim 6, wherein said excess weight is obesity.

8. The method of claim 6, wherein cosmetic weight loss is achieved.

9. The method of claim 6, wherein said composition comprises a salt, conjugate or chemically modified version of oxyntomodulin.

10. The method of claim 6, wherein weight loss is achieved as a result of reduced food intake.

11. The method of claim 6, wherein said composition comprises an analogue of oxyntomodulin wherein the histidine residue at position 1 is replaced by an aromatic moiety carrying a positive charge or by a histidine derivative.

12. The method of claim 6, wherein said composition comprises an analogue of oxyntomodulin wherein one or more of the amino acid residues other than histidine at position 1 are independently replaced by any other amino acid residues, modified or isomeric forms of an amino acid or a corresponding or different amino acid linked via its side chain.

13. The method of claim 6, wherein said composition comprises an analogue of oxyntomodulin wherein 1, 2, 3, 4, or 5 of the amino acid residues are removed from the oxyntomodulin sequence with the exception of histidine at the 1 position.

14. The method of claim 6, wherein said composition comprises an analogue of oxyntomodulin wherein the C-terminus of the oxyntomodulin sequence is modified by the addition of further amino acid residues or other moieties.

15. The method of claim 6, wherein said oxyntomodulin is human oxyntomodulin.

16. A method for the prevention or treatment of excess weight in a mammal, comprising administering a composition comprising oxyntomodulin to said mammal in an amount effective to prevent or treat excess weight in said mammal.

17. The method of claim 16, wherein said excess weight is obesity.

18. The method of claim 16, wherein cosmetic weight loss is achieved.

19. The method of claim 16, wherein weight loss is achieved as a result of reduced food intake.

20. The method of claim 16, wherein said mammal is a human.

21. A method for cosmetic weight loss in a mammal, comprising administering a composition comprising oxyntomodulin to said mammal in an amount effective to achieve cosmetic weight loss in said mammal.

22. The method of claim 21, wherein said cosmetic weight loss is achieved as a result of reduced food intake.

23. The method of claim 21, wherein said mammal is a human.