Treatment of pancreatitis with amylin

• US 20050070472A1
• Filed: 09/24/2003
• Published: 03/31/2005
• Est. Priority Date: 10/18/2002
• Status: Active Grant

• Current Assignee: Astrazeneca Pharmaceuticals LP (Astrazeneca PLC)
• Original Assignee: Astrazeneca Pharmaceuticals LP (Astrazeneca PLC)
• Inventors: Young, Andrew A., Gedulin, Bronislava
• Granted Patent: US 8,168,233 B2
• Time in Patent Office: Days
• US Class Current: 514/9.700
• CPC Class Codes: A61K 38/22 Hormones derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin A61K38/33, e.g. corticotropin A61K38/35

Abstract

The disclosed invention provides for the treatment of pancreatitis, and the alleviation of pain associated therewith, with amylin, amylin agonists and amylin analogs.

Claims

1. A method of treating pancreatitis in a mammalian subject comprising administering to said subject an effective amount of an amylin, an amylin analog or an amylin agonist, wherein said amylin agonist is not a calcitonin.

6. The method of claim 1 wherein said subject is a human.

9. The method of claim 1 wherein said amylin analog is ^25,28,29Pro-h-amylin.

2. A method of relieving pain caused by pancreatitis in a mammalian subject comprising administering to said subject an effective amount of an amylin, an amylin analog or an amylin agonist, wherein said amylin agonist is not a caicitonin.

3. The method of claim 2 wherein administration of the effective amount of an amylin, amylin agonist, or amylin analog simultaneously treats pancreatitis and the pain associated therewith.

4. The method of claim 2 wherein said subject has been diagnosed with pancreatitis.

5. The method of claim 3 wherein said subject has been diagnosed with pancreatitis.

7. The method of claim 2 wherein said subject is a human.

8. The method of claim 3 wherein said subject is a human.

10. The method of claim 2 wherein said amylin analog is ^25,28,29Pro-h-amylin.

11. The method of claim 3 wherein said amylin analog is ^25,28,29Pro-h-amylin.

12. The method of claim 2 further comprising administering to said subject an analgesic.

13. The method of claim 3 further comprising administering to said subject an analgesic.

14. A method of improving a treatment for pancreatitis in a mammalian subject comprising administering an amylin, amylin analog or an amylin agonist in addition to an agent or regimen used to treat pancreatitis, wherein said amylin agonist is not a calcitonin.

15. The method of claim 14 wherein said agent is clinically used to treat pancreatitis.

16. The method of claim 14 wherein said subject is a human.

17. The method of claim 14 wherein said amylin agonist is ^25,28,29Pro-h-amylin.

18. The method of claim 14 further comprising administering to said subject an analgesic.

19. The method of claim 14 wherein the agent is a pancreatic enzyme.

20. The method of claim 14 wherein the regime includes a low-fat diet.