Electrophysiological atlas and applications of same
First Claim
1. A system for creating an atlas for optimal placement of a deep brain stimulator in a brain of a target of interest, comprising:
- a. a data storage device;
b. an image acquisition device for acquiring a brain image volume from the brain of the target of interest;
c. a data acquisition device for acquiring electrophysiological information from the brain of the target of interest; and
d. a data processing device operably coupled to the data storage device, the image acquisition device and the data acquisition device, respectively, and performing the steps of;
(a). relating the acquired electrophysiological information to spatial coordinates in the acquired brain image volume of the target of interest; and
(b). registering the acquired brain image volume of the target of interest to a common image volume of reference so as to create an atlas in which spatial coordinates of the brain of the target of interest are related to atlas coordinates such that the acquired electrophysiological information associated with the related spatial coordinates in the acquired brain image volume of the target of interest can be related to atlas coordinates in the atlas, and vice versa.
2 Assignments
0 Petitions
Accused Products
Abstract
A method of creating an atlas that contains electrophysiological information related to at least one of a plurality of living subjects. In one embodiment, the method includes the steps of choosing a brain image volume as a common image volume of reference, acquiring electrophysiological information for a target of interest, relating the acquired electrophysiological information to spatial coordinates in the brain image volume of the target of interest, and registering the brain image volume of the target of interest to the common image volume of reference so as to create an atlas in which any spatial coordinates of the brain of the target of interest are related to atlas coordinates in the atlas such that the acquired electrophysiological information associated with the related spatial coordinates in the brain image volume of the target of interest can be related to atlas coordinates in the atlas, and vice versa.
-
Citations
81 Claims
-
1. A system for creating an atlas for optimal placement of a deep brain stimulator in a brain of a target of interest, comprising:
-
a. a data storage device;
b. an image acquisition device for acquiring a brain image volume from the brain of the target of interest;
c. a data acquisition device for acquiring electrophysiological information from the brain of the target of interest; and
d. a data processing device operably coupled to the data storage device, the image acquisition device and the data acquisition device, respectively, and performing the steps of;
(a). relating the acquired electrophysiological information to spatial coordinates in the acquired brain image volume of the target of interest; and
(b). registering the acquired brain image volume of the target of interest to a common image volume of reference so as to create an atlas in which spatial coordinates of the brain of the target of interest are related to atlas coordinates such that the acquired electrophysiological information associated with the related spatial coordinates in the acquired brain image volume of the target of interest can be related to atlas coordinates in the atlas, and vice versa. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 73)
-
-
23. A method of creating an atlas that contains electrophysiological information related to at least one of a plurality of living subjects, wherein any portion of a brain of one of the plurality of living subjects and corresponding brain image volume may be identified by a set of corresponding spatial coordinates, comprising the steps of:
-
a. choosing a brain image volume as a common image volume of reference from a plurality of brain image volumes, each of the plurality of brain image volumes being acquired pre-operatively from a brain of one of the plurality of the living subjects;
b. acquiring electrophysiological information for one of the plurality of living subjects;
c. relating the acquired electrophysiological information to spatial coordinates in the brain image volume of the corresponding living subject; and
d. registering the brain image volume of the corresponding living subject to the common image volume of reference so as to create an atlas in which any spatial coordinates of the brain of the corresponding living subject are related to atlas coordinates in the atlas such that the acquired electrophysiological information associated with the related spatial coordinates in the brain image volume of the corresponding living subject can be related to atlas coordinates in the atlas, and vice versa. - View Dependent Claims (24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38)
-
-
39. A system that contains electrophysiological information related to at least one of a plurality of living subjects, wherein any portion of interest in the brain of one of the plurality of living subjects and corresponding brain image volume may be identified by a set of corresponding spatial coordinates, comprising:
-
a. a data storage device; and
b. an atlas stored in the data storage device for containing the electrophysiological information, the atlas being created such that when a brain image volume is registered to the atlas, any spatial coordinates of the brain image volume are related to corresponding atlas coordinates in the atlas, and vice versa. - View Dependent Claims (40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54)
-
-
55. A computer readable medium or media, comprising:
-
a. a data structure relating to an atlas that contains electrophysiological information related to at least one of a plurality of living subjects, wherein any portion of interest for the brain of at least one of the plurality of living subjects and corresponding image volume may be identified by a set of corresponding spatial coordinates; and
b. a user interface in communication with the data structure. - View Dependent Claims (56, 57, 58, 59, 60, 61, 62, 63, 64, 65)
-
-
66. A method for optimal placement of a deep brain stimulator in a brain of a target of interest, comprising the steps of:
-
a. acquiring from the target of interest pre-operatively at least one piece of information associated with a state of brain condition of the target of interest;
b. accessing remotely an atlas that contains electrophysiological information related to a plurality of living subjects, wherein any portion of the brain of one of the plurality of living subjects and corresponding brain image volume may be identified by a set of corresponding spatial coordinates;
c. entering the acquired information from the target of interest to the atlas to find a match between the acquired information and the electrophysiological information contained in the atlas; and
d. automatically obtaining an optimal position in the brain of the target of interest for placing a deep brain stimulator from the matched information. - View Dependent Claims (67, 68, 69, 70, 71, 72, 74, 75, 76, 77)
-
-
78. A method for optimal placement of a deep brain stimulator in a brain of a target of interest, comprising the steps of:
-
a. acquiring from the target of interest pre-operatively at least one piece of information associated with a state of brain condition of the target of interest;
b. accessing remotely an atlas that contains electrophysiological information related to a plurality of living subjects, wherein the atlas is formed with a plurality of clusters, each cluster being related to a state of brain condition and having a plurality of optimal positions for a deep brain stimulator distributed therein;
c. entering the acquired information from the target of interest to the atlas to find a match between the acquired information and the electrophysiological information contained in the atlas; and
d. automatically obtaining an optimal position in the brain of the target of interest for placing a deep brain stimulator from one of the plurality of optimal positions for a deep brain stimulator distributed in the plurality of clusters. - View Dependent Claims (79, 80, 81)
-
Specification