Drug-eluting electrode
First Claim
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1. An apparatus comprising:
- an electrical lead comprising a lead body and an electrical conductor; and
an electrode coupled to the electrical conductor, wherein the electrode includes a coating on at least a portion of a surface of the electrode, the coating including two or more layers, with a first layer adjacent the surface of the electrode including an insulative material and a second layer adjacent the first layer including at least one pharmacological agent.
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Abstract
An apparatus includes an electrical lead comprising a lead body and an electrical conductor, and an electrode coupled to the electrical conductor, wherein the electrode includes a coating on at least a portion of a surface of the electrode, the coating including two or more layers, with a first layer adjacent the surface of the electrode comprising an insulative material and a second layer adjacent the first layer comprising at least one pharmacological agent.
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Citations
45 Claims
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1. An apparatus comprising:
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an electrical lead comprising a lead body and an electrical conductor; and
an electrode coupled to the electrical conductor, wherein the electrode includes a coating on at least a portion of a surface of the electrode, the coating including two or more layers, with a first layer adjacent the surface of the electrode including an insulative material and a second layer adjacent the first layer including at least one pharmacological agent. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A system comprising:
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an electrical pulse generator;
an electrical lead releasably coupled to electrical pulse generator, wherein the electrical lead includes a lead body and an electrical conductor; and
an electrode coupled to the electrical conductor, wherein an outer surface of the electrode is coated with two or more layers comprising an insulative material and at least one pharmacological agent. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. An apparatus comprising:
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an electrical lead comprising a lead body and an electrical conductor; and
an electrode coupled to the electrical conductor, wherein the electrode includes a coating on at least a portion of a surface of the electrode, the coating including two or more layers, with an inner layer including a pharmacological agent in a polymer matrix for regulated, chronic release of the pharmacological agent and an outer layer including only a pharmaceutical agent such that the pharmaceutical agent of the outer layer is exposed to tissue upon implant of the electrode. - View Dependent Claims (31, 32, 33, 34)
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35. A method comprising:
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coating an electrode with a first layer, wherein the first layer comprises a polymeric base coat; and
coating the electrode with a second layer, wherein the second layer comprises a polymer and at least one pharmacological agent, and at least partially coats the first layer. - View Dependent Claims (36, 37, 38, 39, 40, 41, 42, 43, 44, 45)
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Specification